上海交通大学学报（医学版）

上海交通大学学报（医学版） >

2022 , Vol. 42 >Issue 11: 1598 - 1604

DOI: https://doi.org/10.3969/j.issn.1674-8115.2022.11.012

综述

静息状态皮肤电活动在孤独症谱系障碍群体应用的研究进展

  • 马嘉吟 ,
  • 邬钰玮 ,
  • 吴佳佳 ,
  • 唐琳 ,
  • 单春雷 ,
  • 徐建光
展开
  • 1.上海中医药大学附属岳阳中西医结合医院康复医学科，上海 200437
    2.上海中医药大学康复医学院，上海 201203
马嘉吟（1994—），女，主管技师，硕士；电子信箱：jiayin9431@163.com。
徐建光，电子信箱：xjg@shutcm.edu.cn。

收稿日期: 2022-04-04

  录用日期: 2022-10-18

  网络出版日期: 2023-01-04

基金资助

国家重点研发计划(2018YFC2001600);国家自然科学基金(81902301);上海中医药大学附属岳阳中西医结合医院院级基金(2021yyjq07)

收起

Research progress in application of electrodermal activity at rest in autistic spectrum disorder

  • Jiayin MA ,
  • Yuwei WU ,
  • Jiajia WU ,
  • Lin TANG ,
  • Chunlei SHAN ,
  • Jianguang XU
Expand
  • 1.Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
    2.Academy of Rehabilitation Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
XU Jianguang, E-mail: xjg@shutcm.edu.cn.

Received date: 2022-04-04

  Accepted date: 2022-10-18

  Online published: 2023-01-04

Supported by

National Key R&D Program of China(2018YFC2001600);National Science Foundation of China(81902301);Science Foundation of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine(2021yyjq07)

Fold

摘要

孤独症谱系障碍（autism spectrum disorder，ASD）是一种神经发育性障碍，其核心症状主要包括社会交流和互动缺陷，以及兴趣狭窄和重复刻板的行为。ASD核心症状的潜在原因可能为静息状态下存在异常的自主唤醒水平。自主唤醒水平可通过皮肤电活动（electrodermal activity，EDA）来反映。目前研究显示ASD群体的EDA相比正常群体有所差异，并且利用EDA对ASD群体进行亚型划分有潜在的临床意义。EDA检测客观、简便易行，在ASD群体有一定应用优势。但EDA检测仍存一定局限性，目前研究方法尚不统一，结果异质性较高，未来仍需统一规范，并结合其他生物标志物及现代脑功能检测技术进一步揭示ASD群体静息状态异常自主唤醒水平和自主神经系统失调机制。ASD的干预目前以非侵入式脑刺激（non-invasive brain stimulation，NIBS）为主要趋势，尚未形成规范统一的临床治疗方案，有待进一步研究。EDA对ASD群体亚型划分的潜力可能有助于NIBS精准干预方案的制定。该文综述近10年静息状态EDA在ASD群体中的应用进展，以期为进一步研究ASD生物标志物和康复干预方法提供理论依据，为ASD的诊治提供新的视角和思路。

关键词： 孤独症谱系障碍; 皮肤电活动; 自主唤醒水平; 静息状态

本文引用格式

马嘉吟 , 邬钰玮 , 吴佳佳 , 唐琳 , 单春雷 , 徐建光 . 静息状态皮肤电活动在孤独症谱系障碍群体应用的研究进展[J]. 上海交通大学学报（医学版）, 2022 , 42(11) : 1598 -1604 . DOI: 10.3969/j.issn.1674-8115.2022.11.012

Abstract

Autism spectrum disorder (ASD) is a developmental disorder of which the core symptoms are deficits in social communication and interaction, restricted interests as well as repetitive behaviors. The potential cause of core symptoms of ASD may be the presence of abnormal autonomic arousal level in the resting state which can be reflected by electrodermal activity (EDA). Current researches showed that EDA of ASD population was altered from normal healthy population. Additionally, EDA has its clinical potential in differentiating sub-type within ASD population. EDA has its application advantage in ASD population for its objectivity and simple clinical operation. However, the methodology of EDA is not unified and the research results are highly heterogeneous, which indicates the limits of EDA. It is necessary to integrate EDA with other bio-markers and contemporary brain function detection technology, to further reveal the mechanism of abnormal autonomic arousal level and imbalanced autonomic nervous system in the resting state in ASD population. Non-invasive brain stimulation (NIBS) is in main trend of intervention on ASD population, but the standardized and unified clinical intervention has not been formed, which remains to be further studied. Clinical potential of sub-type differentiation by EDA may help to guide accurate NIBS intervention protocol. This paper reviews the application progress of EDA in the resting state in ASD population for the recent 10 years, which is expected to offer theoretical basis for further studying bio-markers and rehabilitation intervention of ASD, and to provide new perspectives for diagnosing and treating ASD.

Key words： autism spectrum disorder (ASD); electrodermal activity (EDA); autonomic arousal level; resting state

参考文献

1 American Psychiatric Association. Diagnostic and statistical manual of mental disorders (5th edition)[M]. Arlington VA: American Psychiatry Publishing, 2013.
2 ZHOU H, XU X, YAN W L, et al. Prevalence of autism spectrum disorder in China: a nationwide multi-center population-based study among children aged 6 to 12 years[J]. Neurosci Bull, 2020, 36(9): 961-971.
3 HUTT C, HUTT S J, LEE D, et al. Arousal and childhood autism[J]. Nature, 1964, 204: 908-909.
4 DESLAURIERS A M, CARLSON C F. Your child is asleep: early infantile autism—etiology, treatment, and parental influences[M]. Homewood: Dorsey Press, 1969.
5 ARORA I, BELLATO A, ROPAR D, et al. Is autonomic function during resting-state atypical in Autism: a systematic review of evidence[J]. Neurosci Biobehav Rev, 2021, 125: 417-441.
6 BOUCSEIN W. Electrodermal Activity[M]. 2th Edition. New York: Springer US, 2012.
7 MATHERSUL D, MCDONALD S, RUSHBY J A. Automatic facial responses to briefly presented emotional stimuli in autism spectrum disorder[J]. Biol Psychol, 2013, 94(2): 397-407.
8 EILAM-STOCK T, XU P F, CAO M, et al. Abnormal autonomic and associated brain activities during rest in autism spectrum disorder[J]. Brain, 2014, 137(Pt 1): 153-171.
9 BUJNAKOVA I, ONDREJKA I, MESTANIK M, et al. Autism spectrum disorder is associated with autonomic underarousal[J]. Physiol Res, 2016, 65(Suppl 5): S673-S682.
10 PARMA V, CELLINI N, GUY L, et al. Profiles of autonomic activity in autism spectrum disorder with and without anxiety[J]. J Autism Dev Disord, 2021, 51(12): 4459-4470.
11 CHANG M C, PARHAM L D, BLANCHE E I, et al. Autonomic and behavioral responses of children with autism to auditory stimuli[J]. Am J Occup Ther, 2012, 66(5): 567-576.
12 RIBY D M, WHITTLE L, DOHERTY-SNEDDON G. Physiological reactivity to faces via live and video-mediated communication in typical and atypical development[J]. J Clin Exp Neuropsychol, 2012, 34(4): 385-395.
13 KUSHKI A, DRUMM E, PLA MOBARAK M, et al. Investigating the autonomic nervous system response to anxiety in children with autism spectrum disorders[J]. PLoS One, 2013, 8(4): e59730.
14 FAJA S, MURIAS M, BEAUCHAINE T P, et al. Reward-based decision making and electrodermal responding by young children with autism spectrum disorders during a gambling task[J]. Autism Res, 2013, 6(6): 494-505.
15 MCCORMICK C, HESSL D, MACARI S L, et al. Electrodermal and behavioral responses of children with autism spectrum disorders to sensory and repetitive stimuli[J]. Autism Res, 2014, 7(4): 468-480.
16 KEITH J M, JAMIESON J P, BENNETTO L. The influence of noise on autonomic arousal and cognitive performance in adolescents with autism spectrum disorder[J]. J Autism Dev Disord, 2019, 49(1): 113-126.
17 KUIPER M W M, VERHOEVEN E W M, GEURTS H M. Stop making noise! auditory sensitivity in adults with an autism spectrum disorder diagnosis: physiological habituation and subjective detection thresholds[J]. J Autism Dev Disord, 2019, 49(5): 2116-2128.
18 DEBOTH K K, REYNOLDS S, LANE S J, et al. Neurophysiological correlates of sensory-based phenotypes in ASD[J]. Child Psychiatry Hum Dev, 2021. DOI: 10.1007/s10578-021-01266-8.
19 MATHERSUL D, MCDONALD S, RUSHBY J A. Autonomic arousal explains social cognitive abilities in high-functioning adults with autism spectrum disorder[J]. Int J Psychophysiol, 2013, 89(3): 475-482.
20 NEUHAUS E, BERNIER R A, BEAUCHAINE T P. Electrodermal response to reward and non-reward among children with autism[J]. Autism Res, 2015, 8(4): 357-370.
21 VISNOVCOVA Z, FERENCOVA N, GRENDAR M, et al. Electrodermal activity spectral and nonlinear analysis-potential biomarkers for sympathetic dysregulation in autism[J]. Gen Physiol Biophys, 2022, 41(2): 123-131.
22 CASANOVA M F, HENSLEY M K, SOKHADZE E M, et al. Effects of weekly low-frequency rTMS on autonomic measures in children with autism spectrum disorder[J]. Front Hum Neurosci, 2014, 8: 851.
23 BILLECI L, TONACCI A, TARTARISCO G, et al. An integrated approach for the monitoring of brain and autonomic response of children with autism spectrum disorders during treatment by wearable technologies[J]. Front Neurosci, 2016, 10: 276.
24 NEUHAUS E, BERNIER R, BEAUCHAINE T P. Brief report: social skills, internalizing and externalizing symptoms, and respiratory sinus arrhythmia in autism[J]. J Autism Dev Disord, 2014, 44(3): 730-737.
25 BHARATH R, MOODITHAYA S S, HALAHALLI H, et al. Evaluation of sympathetic sudomotor responses to auditory stimuli in children with autism spectrum disorders[J]. Indian J Psychiatry, 2020, 62(5): 494-500.
26 CASANOVA M F, VAN KOOTEN I A J, SWITALA A E, et al. Minicolumnar abnormalities in autism[J]. Acta Neuropathol, 2006, 112(3): 287-303.
27 STONER R, CHOW M L, BOYLE M P, et al. Patches of disorganization in the neocortex of children with autism[J]. N Engl J Med, 2014, 370(13): 1209-1219.
28 COURCHESNE E, PIERCE K. Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection[J]. Curr Opin Neurobiol, 2005, 15(2): 225-230.
29 邬钰玮, 李源莉, 单春雷. 经颅直流电刺激在自闭症谱系障碍中的应用及展望[J]. 中国康复, 2021, 36(9): 560-563.
29 WU Y W, LI Y L, SHAN C L. The application and prospect of transcranial direct current stimulation in autism spectrum disorder[J]. Chin J Rehabil, 2021, 36(9): 560-563.
30 YAVARI F, JAMIL A, MOSAYEBI SAMANI M, et al. Basic and functional effects of transcranial electrical stimulation (tES): an introduction[J]. Neurosci Biobehav Rev, 2018, 85: 81-92.
31 CARDINALE R C, SHIH P, FISHMAN I, et al. Pervasive rightward asymmetry shifts of functional networks in autism spectrum disorder[J]. JAMA Psychiatry, 2013, 70(9): 975-982.
32 AMATACHAYA A, AUVICHAYAPAT N, PATJANASOONTORN N, et al. Effect of anodal transcranial direct current stimulation on autism: a randomized double-blind crossover trial[J]. Behav Neurol, 2014, 2014: 173073.
33 ANTUNES G, FARIA DA SILVA S F, SIMOES DE SOUZA F M. Mirror neurons modeled through spike-timing-dependent plasticity are affected by channelopathies associated with autism spectrum disorder[J]. Int J Neural Syst, 2018, 28(5): 1750058.
34 HADOUSH H, NAZZAL M, ALMASRI N A, et al. Therapeutic effects of bilateral anodal transcranial direct current stimulation on prefrontal and motor cortical areas in children with autism spectrum disorders: a pilot study[J]. Autism Res, 2020, 13(5): 828-836.
35 COLE E J, BARRACLOUGH N E, ANDREWS T J. Reduced connectivity between mentalizing and mirror systems in autism spectrum condition[J]. Neuropsychologia, 2019, 122: 88-97.
36 BARAHONA-CORRêA J B, VELOSA A, CHAINHO A, et al. Repetitive transcranial magnetic stimulation for treatment of autism spectrum disorder: a systematic review and meta-analysis[J]. Front Integr Neurosci, 2018, 12: 27.
37 吴扬, 王璐, 陈新贵, 等. 经颅磁刺激治疗常见脑疾病社会认知功能障碍研究进展[J]. 中国神经精神疾病杂志, 2020, 46(3): 172-175.
37 WU Y, WANG L, CHEN X G, et al. Research progress of transcranial magnetic stimulation in the treatment of psychosocial dysfunction in common brain diseases[J]. Chin J Nerv Ment Dis, 2020, 46(3): 172-175.
38 HA S, SOHN I J, KIM N, et al. Characteristics of brains in autism spectrum disorder: structure, function and connectivity across the lifespan[J]. Exp Neurobiol, 2015, 24(4): 273-284.
39 MOHAMMAD-REZAZADEH I, FROHLICH J, LOO S K, et al. Brain connectivity in autism spectrum disorder[J]. Curr Opin Neurol, 2016, 29(2): 137-147.
40 VAN ELST L T, RIEDEL A, MAIER S. Autism as a disorder of altered global functional and structural connectivity[J]. Biol Psychiatry, 2016, 79(8): 626-627.
Options
文章导航

/

〈 〉