收稿日期: 2022-03-19
录用日期: 2022-06-18
网络出版日期: 2023-02-28
基金资助
国家重点研发计划(2018YFC1704300);国家自然科学基金(81973876);教育部创新团队发展计划(IRT1270);科技部重点领域创新团队项目(2015RA4002)
Research progress in the roles of Notch signaling pathway during fracture healing
Received date: 2022-03-19
Accepted date: 2022-06-18
Online published: 2023-02-28
Supported by
National Key R&D Program of China(2018YFC1704300);National Natural Science Foundation of China(81973876);Ministry of Education Innovation Team Development Program(IRT1270);Innovation Team Project in Key Fields of Ministry of Science and Technology(2015RA4002)
骨折是人类最常见的大器官损伤，从骨折发生至骨重建完成需经历数月甚至更长的时间，严重者可发生延迟愈合甚至骨不连。目前骨折的治疗主要追求完成临床愈合及骨性愈合，愈合过程划分为早、中、晚3期。多种因素影响愈合过程的快慢，其中信号通路和细胞因子在骨折愈合中发挥着重要作用，因此了解信号通路和细胞因子的重要作用对治疗骨折、促进骨折的愈合具有重要意义。近年来研究表明，Notch信号通路可影响骨折愈合过程中的细胞增殖分化、炎症反应、骨重建、血管生成和神经再生等多个环节，且其变化与力学刺激等因素也密切相关，因此了解骨折愈合过程中Notch信号通路分子机制对于治疗骨折疾病、避免延迟性愈合及骨不连具有重要意义。该文从上述细胞增殖分化、炎症反应、骨重建、血管生成、神经再生和力学刺激等多个环节角度分别综述了Notch信号通路在骨折愈合不同环节中作用的研究进展，希冀为骨折愈合治疗提供新的研究思路及治疗策略。
过丽强 , 赵世天 , 舒冰 . Notch信号通路在骨折愈合过程中作用的研究进展[J]. 上海交通大学学报（医学版）, 2023 , 43(2) : 222 -229 . DOI: 10.3969/j.issn.1674-8115.2023.02.012
Fracture is the most common large-organ injury in humans. It takes several months or even longer from the onset to the completion of bone reconstruction. In severe cases, delayed healing or even bone discontinuity can occur. The current treatment of fractures mainly pursues the completion of clinical healing and bone healing, and the healing process is divided into three stages: early, intermediate and late. Various factors affect the speed of the healing process, among which signaling pathways and cytokines play an important role in fracture healing, so understanding the important role of signaling pathways and cytokines is important for treating fractures and promoting fracture healing. Recent studies have shown that the Notch signaling pathway can affect cell proliferation and differentiation, inflammatory response, bone reconstruction, angiogenesis and nerve regeneration during fracture healing, and its changes are also closely related to mechanical stimulation and other factors. Therefore, this paper reviews the research progress in the role of Notch signaling pathway in various aspects of fracture healing from the perspectives of cell proliferation and differentiation, inflammatory response, bone reconstruction, angiogenesis, nerve regeneration and mechanical stimulation, and provides new research directions and therapeutic strategies for fracture healing treatment.
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