收稿日期: 2024-04-18
录用日期: 2024-09-03
网络出版日期: 2024-12-16
基金资助
国家自然科学基金(82271664);上海市卫生健康委员会科研项目(202240343);上海市胚胎源性疾病重点实验室开放课题基金(Shelab2022ZD01);上海交通大学“交大之星”计划“医工交叉研究基金”(YG2022ZD028)
Research progress in the correlation between chronic stress and ovarian dysfunction
Received date: 2024-04-18
Accepted date: 2024-09-03
Online published: 2024-12-16
Supported by
National Natural Science Foundation of China(82271664);Scientific Research Program of Shanghai Municipal Health Commission(202240343);Opening Project Foundation of Shanghai Key Laboratory of Embryo Original Diseases(Shelab2022ZD01);Medical-Engineering Cross Research of Shanghai Jiao Tong University(YG2022ZD028)
卵巢是女性重要的生殖器官。卵巢功能的减退不仅影响其生育功能，更会导致女性生活质量下降。近年来的研究表明，慢性应激可通过下丘脑-垂体-肾上腺轴分泌的促肾上腺皮质激素释放激素、皮质酮和皮质醇以及交感-肾上腺-髓质轴和交感神经系统分泌的肾上腺素和去甲肾上腺素等激素直接或间接影响下丘脑-垂体-卵巢轴，并引起卵巢功能减退，包括卵巢原始卵泡过度激活、窦前卵泡和排卵前卵泡减少、卵母细胞质量下降及颗粒细胞凋亡等。该文就慢性应激与卵巢功能减退的相关性和潜在机制进行综述。
关键词： 早发性卵巢功能不全; 卵巢功能; 慢性应激; 下丘脑-垂体-肾上腺轴; 下丘脑-垂体-卵巢轴
韦柳彤 , 赖东梅 . 慢性应激与卵巢功能减退的相关性研究进展[J]. 上海交通大学学报（医学版）, 2024 , 44(12) : 1601 -1606 . DOI: 10.3969/j.issn.1674-8115.2024.12.014
The ovary is an important reproductive organ for women. Decreased ovarian function not only affects the reproductive capabilities, but also leads to the decline of women′s quality of life. Recent studies have shown that chronic stress affects the hypothalamic-pituitary-ovary axis directly or indirectly and leads to ovarian dysfunction-including excessive activation of primordial follicles, a reduction in preantral and preovulatory follicles, decline of oocyte quality, and granulosa cell apoptosis, through corticotropin-releasing hormone, corticosterone and cortisol secreted by the hypothalamic-pituitary-adrenal axis, as well as epinephrine and norepinephrine released by the sympathetic-adrenal-medullary axis and sympathetic nervous system. This article reviews the correlation between chronic stress and ovarian dysfunction, along with the potential mechanisms.
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