收稿日期: 2024-01-30
录用日期: 2024-06-28
网络出版日期: 2024-12-28
基金资助
河北省自然科学基金精准医学联合基金培育项目(H2022206523)
Heterogeneous nuclear ribonucleoprotein H1 and its function in tumor development and metastasis
Received date: 2024-01-30
Accepted date: 2024-06-28
Online published: 2024-12-28
Supported by
Incubation Program of Precision Medicine Joint Foundation, Natural Science Foundation of Hebei Province(H2022206523)
核不均一核糖核蛋白（heterogeneous nuclear ribonucleoprotein，hnRNP）与核不均一RNA（heterogenous nuclear RNA，hnRNA）结合并形成复合物，参与调控RNA的剪接和转运。hnRNPH1属于hnRNP家族的一员，在神经系统和生殖系统的发育等生理过程中发挥重要的作用。hnRNPH1在多种肿瘤组织和肿瘤细胞中高表达，且其高表达与患者预后不良相关。hnRNPH1通过调控基因的可变剪接、调控基因的表达、与其他基因形成融合基因、参与表观遗传调控等作用，促进肿瘤细胞的生长和转移。近年来研究显示，hnRNPH1可作为部分肿瘤的潜在生物标志物，以其为靶点的靶向药物已在黑色素瘤小鼠模型中取得初步疗效。该文对hnRNPH1在恶性肿瘤发生和发展过程中发挥的作用及其研究进展进行综述。
张宗稳 , 冯莉 , 范志松 . hnRNPH1在肿瘤生长和转移中作用的研究进展[J]. 上海交通大学学报（医学版）, 2024 , 44(12) : 1615 -1620 . DOI: 10.3969/j.issn.1674-8115.2024.12.016
Heterogeneous nuclear ribonucleoprotein (hnRNP) and heterogeneous nuclear RNA (hnRNA) form complexes that regulate RNA splicing and transportation. hnRNPH1 is a member of the hnRNP family of proteins and plays an important role in physiological processes, including embryonic development of the nervous and reproductive systems. hnRNPH1 is highly expressed in various tumor tissues and tumor cells, and its overexpression correlates with poor prognosis in patients. hnRNPH1 enhances tumor cell proliferation and metastasis through the regulation of alternative splicing of genes, modulation of gene expression, formation of fusion genes with other genes, and involvement in epigenetic regulation.Recent studies have shown that hnRNPH1 could serve as a potential biomarker for certain tumors, and hnRNPH1-targeting drugs show preliminary efficacy in a mouse model of melanoma. This article reviews the role and research progress of hnRNPH1 in the initiation and progression of malignant tumors.
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