上海交通大学学报（医学版）

上海交通大学学报（医学版） >

2025 , Vol. 45 >Issue 8: 1074 - 1078

DOI: https://doi.org/10.3969/j.issn.1674-8115.2025.08.016

病例报告

重型再生障碍性贫血合并蜡样芽孢杆菌多发感染1例

  • 周慧茹 ,
  • 张丽琴 ,
  • 张晓星 ,
  • 孙志江
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  • 甘肃省人民医院重症医学科二病区，兰州 730000
张丽琴，副主任医师，硕士；电子信箱：zhangliqin1984@163.com。

收稿日期: 2025-03-06

  录用日期: 2025-04-28

  网络出版日期: 2025-08-18

基金资助

甘肃省医学检验临床医学研究中心项目(21JR7RA676);兰州市科技计划项目(2023-2-100);甘肃省人民医院科研基金(24GSSYB-9)

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Case report of severe aplastic anemia complicated by multiple Bacillus cereus infections

  • ZHOU Huiru ,
  • ZHANG Liqin ,
  • ZHANG Xiaoxing ,
  • SUN Zhijiang
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  • Department of Intensive Care Unit 2, Gansu Provincial Hospital, Lanzhou 730000, China
ZHANG Liqin, E-mail: zhangliqin1984@163.com.

Received date: 2025-03-06

  Accepted date: 2025-04-28

  Online published: 2025-08-18

Supported by

Gansu Medical Laboratory Clinical Medicine Research Center(21JR7RA676);Lanzhou City Science and Technology Plan Projects(2023-2-100);Gansu Provincial Hospital Research Fund(24GSSYB-9)

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摘要

重型再生障碍性贫血患者本身存在粒细胞减少，在接受免疫抑制治疗后，更易发生感染，常合并多系统并发症。蜡样芽孢杆菌（Bacillus cereus，B. cereus）分布广泛，可在健康人群定植，是典型的机会性致病菌，其感染途径多样。粒细胞缺乏是多种血液系统疾病的常见表现之一，存在粒细胞缺乏的血液系统疾病患者更容易感染B. cereus。该文报道1例重型再生障碍性贫血患者，在免疫抑制治疗后的粒细胞缺乏期，发生B. cereus菌血症同时发生多处脓肿的病例。重型再生障碍性贫血合并B. cereus菌血症伴多处脓肿的病例较为罕见。该文结合相关文献，深入分析诊疗过程，总结经验，以期提升此类患者的临床诊疗水平。

关键词： 再生障碍性贫血; 蜡样芽孢杆菌; 菌血症; 脓肿

本文引用格式

周慧茹 , 张丽琴 , 张晓星 , 孙志江 . 重型再生障碍性贫血合并蜡样芽孢杆菌多发感染1例[J]. 上海交通大学学报（医学版）, 2025 , 45(8) : 1074 -1078 . DOI: 10.3969/j.issn.1674-8115.2025.08.016

Abstract

Patients with severe aplastic anemia (SAA) often present with neutropenia, and are particularly susceptible to infections, especially following immunosuppressive therapy. Bacillus cereus is a ubiquitous, opportunistic pathogen capable of colonizing healthy individuals and causing infections through various routes. Neutropenia is a common feature in many hematologic disorders, placing affected patients at higher risk for Bacillus cereus infections. This report describes a rare case of Bacillus cereus bacteremia with multiple abscesses in a patient with SAA during the neutropenic phase following immunosuppressive therapy. Given the rarity of such presentations, relevant literature was reviewed and the diagnostic and treatment process was analyzed in detail, with the aim of providing clinical insights and improving the management of similar cases.

Key words： aplastic anemia; Bacillus cereus; bacteremia; abscess

参考文献

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