收稿日期: 2025-06-05
录用日期: 2025-09-28
网络出版日期: 2025-12-28
基金资助
国家自然科学基金(82270521)
Application progress of nanomaterial-based delivery systems in atherosclerosis
Received date: 2025-06-05
Accepted date: 2025-09-28
Online published: 2025-12-28
Supported by
National Natural Science Foundation of China(82270521)
动脉粥样硬化是一种慢性血管炎症，其病灶分散且位置深在，是心血管疾病发病的主要原因。高效的药物递送是提升其治疗效果的关键要素。纳米材料凭借其独特的理化特性， 在药物递送中优势显著，通过功能化修饰可实现靶向递送，增强药物在病变部位的富集，减少脱靶分布，提高治疗安全性与有效性。纳米递送系统按材料特性可分为脂基纳米载体、聚合物纳米载体、无机纳米载体和仿生纳米载体四大类，其多功能复合体系设计更支持多模态协同治疗，如光热转换、磁响应成像引导治疗等，对提高动脉粥样硬化治疗效率具有重要意义。该文系统梳理了纳米载体在动脉粥样硬化治疗中的应用研究进展，重点探讨不同类型纳米载体的构建、靶向机制及多模态应用，涵盖了从基础研究到临床前及部分临床实验的代表性成果，并展望未来基于纳米技术的治疗策略发展方向，以期为该领域的进一步研究与临床转化提供参考。
陈亮 , 吴彪 , 袁良喜 . 基于纳米材料的递送系统在动脉粥样硬化诊疗中的应用进展[J]. 上海交通大学学报（医学版）, 2025 , 45(12) : 1687 -1693 . DOI: 10.3969/j.issn.1674-8115.2025.12.015
Atherosclerosis (AS), a chronic vascular inflammatory disease characterized by scattered and deep-seated lesions, is a major cause of cardiovascular disease. Efficient drug delivery is crucial for enhancing therapeutic efficacy in this condition. Nanomaterials exhibit significant advantages in drug delivery systems owing to their unique physicochemical properties. Through targeted surface functionalization, they enable precise drug targeting, promote enhanced accumulation at pathological sites, reduce off-target biodistribution, and ultimately improve both therapeutic efficacy and safety profiles. Nano-delivery systems, categorized based on material characteristics into four major classes—lipid-based, polymeric, inorganic, and biomimetic nanocarriers—have multifunctional composite designs that support multimodal synergistic therapies (e.g., photothermal conversion and magnetic-responsive imaging-guided therapy). These approaches hold significant potential for enhancing therapeutic efficiency in AS management. This review synthesizes recent advances in nanocarrier-based strategies for AS management, focusing on the synthesis of diverse nanocarrier types, targeting mechanisms, and multimodal applications. It covers representative achievements ranging from basic research to preclinical studies and partial clinical trials, while outlining future development directions for nanotechnology-based therapeutic strategies and providing critical perspectives on technical innovations and persistent translational hurdles in this field.
Key words： nanomaterial; nanotechnology; atherosclerosis
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