目的 评价半纤维素单纯闭合性敷料Veloderm^®促进烧伤整形手术刃厚供皮区创面愈合的有效性和安全性。方法 采用随机、开放、阳性药平行对照的试验方法进行研究。将Veloderm^®外敷于首次烧伤或整形手术刃厚供皮区创面（试验组，n=24），以临床常用且疗效确定的凡士林油纱布作为阳性药平行对照（对照组, n=24），比较两组创面愈合时间以及手术后第7天的创面愈合百分率、累计痊愈率及总有效率，观察不良反应的发生情况，评价Veloderm^®对创面愈合的促进作用以及使用的安全性。结果 试验组和对照组创面愈合时间分别为(6.25±1.11) d和(7.00±0.93) d，两组间差异有统计学意义（P<0.05）。术后第7天，试验组创面愈合百分率、累计痊愈率和总有效率分别为（97.92±5.69）%、87.50%和100%，显著高于对照组的（93.37±8.92）%、58.33%和83.33%，差异均有统计学意义(P<0.05)。两组均无药物相关不良反应发生病例。结论 纤维素单纯闭合性敷料Veloderm^®外敷对烧伤或整形手术供皮区创面的愈合具有显著促进作用，且使用安全性良好。

Objective To investigate the efficacy and safety of hemicellulose dressing Veloderm^® for wound healing of donor sites of burn or reconstruction. Methods A randomized, open and controlled clinical trial was conducted. Hemicellulose dressing Veloderm^® (test group, n=24) and commonly used Vaseline gauze (positive parallel control)(control group, n=24) were applied to the donor sites of burn or reconstruction, respectively. The time of wound healing, and wound healing rates, cumulative healing rates and total effective rates 7 d after operation were compared between two groups, the adverse effects were observed, and the efficacy and safety of Veloderm^® for wound healing were evaluated. Results There was significant difference in the healing time of donor sites between test group and control group [(6.25±1.11) d vs (7.00±0.93）d, P<0.05]. The wound healing rate, cumulative healing rate and total effective rate 7 d after operation in test group were significantly higher than those in control group [(97.92±5.69)% vs (93.37±8.92)%, 87.50% vs 58.33%,100% vs 83.33%; P<0.05 for all]. There was no medicine-related adverse effect in both groups. Conclusion Hemicellulose dressing Veloderm^® is effective and safe for wound healing of donor sites of burn or reconstruction.