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异位子宫内膜17β-羟基类固醇脱氢酶2缺乏的分子机制

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  • 上海交通大学 医学院附属新华医院妇产科, 上海 200092
李笛悠(1986—), 女, 硕士生;电子信箱: lidiyou_u@163.com。

网络出版日期: 2011-04-28

Mechanism of 17 β-hydroxysteroid dehydrogenase-2 deficiency in ectopic endometrium

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  • Department of Obstetrics and Gynecology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China

Online published: 2011-04-28

摘要

正常子宫内膜凋亡受雌激素的影响,17β-羟基类固醇脱氢酶2(17β-HSD2)在调控雌激素生物活性中起主要作用,其量和活性依赖孕激素的调控,孕激素通过与孕激素受体结合起作用。在子宫内膜异位症患者的异位内膜中,17β-HSD2表达下降。文章综述17β-HSD2对雌激素活性的调控及对子宫内膜生长的调节,以及17β-HSD2的表达与孕激素及其相应受体结构、基因、亚型、功能的相关性,并探讨17β-HSD2在子宫内膜异位症的发生、发展、治疗、预后中的作用。

本文引用格式

李笛悠, 张 萍 . 异位子宫内膜17β-羟基类固醇脱氢酶2缺乏的分子机制[J]. 上海交通大学学报(医学版), 2011 , 31(4) : 510 . DOI: 10.3969/j.issn.1674-8115.2011.04.030

Abstract

The apoptosis of normal endometrium is affected by estrogen. The biological activity of estrogen is mainly adjusted by 17β-hydroxysteroid dehydrogenase-2 (17β-HSD2), whose activity and quantity are dependent on progesterone that works in combination with its receptors. However, 17β-HSD2 is decreased in the ectopic endometrium of patients with endometriosis. This review is to introduce the paths how 17β-HSD2 inactivates estradiol and adjusts the growth of endometrium, and the relationship between the expression of 17β-HSD2 and the formation, gene, isoforms and function of progesterone and progesterone receptor, based on which the significance of 17β-HSD2 in the genesis, development, treatment and prognosis of endometriosis is discussed.

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