目的 探讨儿童肝母细胞瘤的临床诊断与治疗方案。方法 对上海交通大学医学院附属新华医院2007年1月—2010年2月收治的12例儿童肝母细胞瘤患者的诊断、治疗及随访情况进行总结和分析。结果 按国际儿童肿瘤协会（SIOP）Pretest临床分期：Ⅱ期 1例，Ⅲ期 1例，Ⅳ期10例。12例均予化疗与手术联合治疗。1例Ⅱ期患儿和1例Ⅲ期患儿均存活；10例Ⅳ期患儿中，8例存活，1例停药后脑转移死亡，1例治疗无效死亡。结论 肿瘤完整切除是儿童肝母细胞瘤治疗的关键；化疗对实施根治性手术及预防肿瘤复发有重要意义。

Objective To investigate the diagnosis and treatment of hepatoblastoma in children. Methods The diagnosis, treatment and long-term follow-up of 12 children with hepatoblastoma during January 2007 and February 2010 were analysed. Results According to International Society of Pediatric Oncology (SIOP) Pretest staging system, there was 1 case of stage Ⅱ, 1 case of stage Ⅲ and 10 cases of stage Ⅳ.  All the 12 cases were treated with both chemotherapy and surgery. Both the case of stage Ⅱ and case of stage Ⅲ survived. Among the 10 cases of stage Ⅳ, 8 survived, 1 died of brain metastasis after drug withdrawl, and the other died due to no response to treatment. Conclusion Radical resection of tumor plays a key role in the treatment of hepatoblastoma in children. Chemotherapy is of great significance in the implementation of radical operation and prevention of tumor recurrence.