›› 2011, Vol. 31 ›› Issue (4): 517-.doi: 10.3969/j.issn.1674-8115.2011.04.032

• 短篇论著 • 上一篇    下一篇

12例儿童肝母细胞瘤的诊断与治疗

盛 琦1, 袁晓军1, 张 勤1, 王 俊2, 施诚仁2   

  1. 上海交通大学 医学院附属新华医院 1.儿内科, 2.儿外科, 上海 200092
  • 出版日期:2011-04-28 发布日期:2011-04-28
  • 作者简介:盛 琦(1966—), 女, 副主任医师, 学士;电子信箱: drshengqi@Yahoo.com.cn。

Diagnosis and treatment of 12 children with hepatoblastoma

SHENG Qi1, YUAN Xiao-jun1, ZHANG Qin1, WANG Jun2, SHI Cheng-ren2   

  1. 1.Department of Paediatrics, 2.Department of Paediatric Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2011-04-28 Published:2011-04-28

摘要:

目的 探讨儿童肝母细胞瘤的临床诊断与治疗方案。方法 对上海交通大学医学院附属新华医院2007年1月—2010年2月收治的12例儿童肝母细胞瘤患者的诊断、治疗及随访情况进行总结和分析。结果 按国际儿童肿瘤协会(SIOP)Pretest临床分期:Ⅱ期 1例,Ⅲ期 1例,Ⅳ期10例。12例均予化疗与手术联合治疗。1例Ⅱ期患儿和1例Ⅲ期患儿均存活;10例Ⅳ期患儿中,8例存活,1例停药后脑转移死亡,1例治疗无效死亡。结论 肿瘤完整切除是儿童肝母细胞瘤治疗的关键;化疗对实施根治性手术及预防肿瘤复发有重要意义。

关键词: 儿童肝母细胞瘤, 化疗, 手术

Abstract:

Objective To investigate the diagnosis and treatment of hepatoblastoma in children. Methods The diagnosis, treatment and long-term follow-up of 12 children with hepatoblastoma during January 2007 and February 2010 were analysed. Results According to International Society of Pediatric Oncology (SIOP) Pretest staging system, there was 1 case of stage Ⅱ, 1 case of stage Ⅲ and 10 cases of stage Ⅳ.  All the 12 cases were treated with both chemotherapy and surgery. Both the case of stage Ⅱ and case of stage Ⅲ survived. Among the 10 cases of stage Ⅳ, 8 survived, 1 died of brain metastasis after drug withdrawl, and the other died due to no response to treatment. Conclusion Radical resection of tumor plays a key role in the treatment of hepatoblastoma in children. Chemotherapy is of great significance in the implementation of radical operation and prevention of tumor recurrence.

Key words: child hepatoblastoma, chemotherapy, surgery