钾氯共转运体-2（KCC2）是阳离子和氯离子共转运体家族中的一员，广泛分布于中枢神经系统（CNS），主要负责把细胞内的氯离子泵出细胞外，维持抑制性神经元的抑制功能所必需的低氯环境。KCC2的下调参与一些神经系统疾病和疼痛的发生和发展，而KCC2本身亦受多种因素的调节。该文就KCC2的调节机制作一综述。

Potassium-chloride co-transporter 2 (KCC2) is a member of cation-chloride co-transporters family, which expresses extensively in central nervous system. KCC2 is responsible for the maintenance of low concentration of intracellular chloride by excluding intracellular chloride outside the cells, which is the key mechanism of normal functions of inhibitory neurons. The down-regulation of KCC2 expression participates in the development and maintenance of several nervous system diseases and pain, and KCC2 expression is regulated by many factors. The mechanism of regulation of KCC2 is reviewed in this paper.