上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (5): 659-.doi: 10.3969/j.issn.1674-8115.2011.05.028

• 综述 • 上一篇    下一篇

钾氯共转运体-2调节机制的研究进展

赵华平, 薛庆生, 于布为, 张富军   

  1. 上海交通大学 |医学院附属瑞金医院麻醉科, 上海 200025
  • 出版日期:2011-05-28 发布日期:2011-05-27
  • 通讯作者: 于布为, 电子信箱: yubuwei@yahoo.com.cn。
  • 作者简介:赵华平（1982—）, 女, 硕士生；电子信箱: 2008.huaping@163.com。
  • 基金资助:

    国家自然科学基金（30400421, 30672020）

Research progress of mechanism of potassium-chloride co-transporter-2 regulation

ZHAO Hua-ping, XUE Qing-sheng, YU Bu-wei, ZHANG Fu-jun   

  1. Department of Anesthesiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2011-05-28 Published:2011-05-27
  • Supported by:

    National Natural Science Foundation of China, 30400421, 30672020

PDF (PC)

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摘要：

钾氯共转运体-2（KCC2）是阳离子和氯离子共转运体家族中的一员，广泛分布于中枢神经系统（CNS），主要负责把细胞内的氯离子泵出细胞外，维持抑制性神经元的抑制功能所必需的低氯环境。KCC2的下调参与一些神经系统疾病和疼痛的发生和发展，而KCC2本身亦受多种因素的调节。该文就KCC2的调节机制作一综述。

关键词: 钾氯共转运体-2, 调节, 疼痛

Abstract:

Potassium-chloride co-transporter 2 (KCC2) is a member of cation-chloride co-transporters family, which expresses extensively in central nervous system. KCC2 is responsible for the maintenance of low concentration of intracellular chloride by excluding intracellular chloride outside the cells, which is the key mechanism of normal functions of inhibitory neurons. The down-regulation of KCC2 expression participates in the development and maintenance of several nervous system diseases and pain, and KCC2 expression is regulated by many factors. The mechanism of regulation of KCC2 is reviewed in this paper.

Key words: potassium-choride co-transporter 2, regulation, pain