短篇论著

CK7和S100A1在嫌色细胞肾细胞癌和肾嗜酸细胞腺瘤中的表达及鉴别意义

展开
  • 上海交通大学 医学院附属仁济医院病理科, 上海 200001
宣蓓蕾(1979—), 女, 技师;电子信箱: gigixbl1129@hotmail.com。

网络出版日期: 2013-02-06

Diagnostic significance of expression of CK7 and S100A1 in chromophobe renal cell carcinoma and renal oncocytoma

Expand
  • Department of Pathology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China

Online published: 2013-02-06

摘要

目的 研究CK7和S100A1在嫌色细胞肾细胞癌(chRCC)和肾嗜酸细胞腺瘤中的表达及鉴别诊断。方法 采用免疫组织化学染色法,观察22例chRCC和20例肾嗜酸细胞腺瘤组织中CK7和S100A1表达。结果免疫组织化学染色法检测显示:22例chRCC中20例(90.9%)CK7呈阳性表达,20例肾嗜酸细胞腺瘤中仅2例(10.0%)CK7呈阳性表达(P=0.000);14例(63.6%)chRCC的S100A1呈阳性表达,19例(95.0%)肾嗜酸细胞腺瘤中的S100A1呈阳性表达(P=0.003)。结论 CK7和S100A1免疫组织化学染色结果有助于chRCC与肾嗜酸细胞腺瘤的鉴别诊断。

本文引用格式

宣蓓蕾, 陈以明, 刘 强 . CK7和S100A1在嫌色细胞肾细胞癌和肾嗜酸细胞腺瘤中的表达及鉴别意义[J]. 上海交通大学学报(医学版), 2013 , 33(1) : 118 . DOI: 10.3969/j.issn.1674-8115.2013.01.024

Abstract

Objective To investigate the expression and diagnostic significance of CK7 and S100A1 in chromophobe renal cell carcinoma (chRCC) and renal oncocytoma. Methods The expression of CK7 and S100A1 in 22 cases of chRCC and 20 cases of renal oncocytoma was determined by immunohistochemical staining. Results Positive expression of CK7 was observed in 20 cases (90.9%) of chRCC and 2 cases (10.0%) of renal oncocytoma (P=0.000). Positive expression of S100A1 was observed in 14 cases (63.6%) of chRCC and 19 cases (95.0%) of renal oncocytoma (P=0.003). Conclusion Immunohistochemical staining of CK7 and S100A1 may be helpful for differential diagnosis of chRCC and renal oncocytoma.

文章导航

/