上海交通大学学报（医学版）

›› 2013, Vol. 33 ›› Issue (1): 118-.doi: 10.3969/j.issn.1674-8115.2013.01.024

• 短篇论著 • 上一篇    下一篇

CK7和S100A1在嫌色细胞肾细胞癌和肾嗜酸细胞腺瘤中的表达及鉴别意义

宣蓓蕾, 陈以明, 刘 强   

  1. 上海交通大学 医学院附属仁济医院病理科, 上海 200001
  • 出版日期:2013-01-28 发布日期:2013-02-06
  • 通讯作者: 刘 强, 电子信箱: liuq1963@sohu.com。
  • 作者简介:宣蓓蕾（1979—）, 女, 技师；电子信箱: gigixbl1129@hotmail.com。

Diagnostic significance of expression of CK7 and S100A1 in chromophobe renal cell carcinoma and renal oncocytoma

XUAN Bei-lei, CHEN Yi-ming, LIU Qiang   

  1. Department of Pathology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China
  • Online:2013-01-28 Published:2013-02-06

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摘要：

目的 研究CK7和S100A1在嫌色细胞肾细胞癌（chRCC）和肾嗜酸细胞腺瘤中的表达及鉴别诊断。方法 采用免疫组织化学染色法，观察22例chRCC和20例肾嗜酸细胞腺瘤组织中CK7和S100A1表达。结果免疫组织化学染色法检测显示：22例chRCC中20例（90.9％）CK7呈阳性表达，20例肾嗜酸细胞腺瘤中仅2例（10.0％）CK7呈阳性表达（P=0.000）；14例（63.6％）chRCC的S100A1呈阳性表达，19例（95.0％）肾嗜酸细胞腺瘤中的S100A1呈阳性表达（P=0.003）。结论 CK7和S100A1免疫组织化学染色结果有助于chRCC与肾嗜酸细胞腺瘤的鉴别诊断。

关键词: 嫌色细胞肾细胞癌, 肾嗜酸细胞腺瘤, 细胞角蛋白7, S100A1

Abstract:

Objective To investigate the expression and diagnostic significance of CK7 and S100A1 in chromophobe renal cell carcinoma (chRCC) and renal oncocytoma. Methods The expression of CK7 and S100A1 in 22 cases of chRCC and 20 cases of renal oncocytoma was determined by immunohistochemical staining. Results Positive expression of CK7 was observed in 20 cases (90.9%) of chRCC and 2 cases (10.0%) of renal oncocytoma (P=0.000). Positive expression of S100A1 was observed in 14 cases (63.6%) of chRCC and 19 cases (95.0%) of renal oncocytoma (P=0.003). Conclusion Immunohistochemical staining of CK7 and S100A1 may be helpful for differential diagnosis of chRCC and renal oncocytoma.

Key words: chromophobe renal cell carcinoma, renal oncocytoma, cytokeratin 7, S100A1