上海交通大学学报（医学版）

›› 2013, Vol. 33 ›› Issue (1): 114-.doi: 10.3969/j.issn.1674-8115.2013.01.023

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硒结合蛋白1作为肿瘤标志物的研究进展

张晨静1, 潘 驰2, 潘文胜1, 陈光兰3   

  1. 浙江大学 医学院附属第二医院 1.消化内科, 2.肿瘤内科 浙江大学肿瘤研究所, 杭州 310009； 3.浙江省丽水市人民医院消化内科, 丽水 323000
  • 出版日期:2013-01-28 发布日期:2013-02-06
  • 通讯作者: 潘文胜, 电子信箱: wspan223@yahoo.com。
  • 作者简介:张晨静（1986—）, 女, 硕士生；电子信箱: zhangcj2000@sohu.com。

Research progress on selenium binding protein 1 as a novel tumor biomarker

ZHANG Chen-jing1, PAN Chi2, PAN Wen-sheng1, CHEN Guang-lan3   

  1. 1.Department of Gastroenterology, 2.Department of Oncology, Institute of Cancer Research, Zhejiang University, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China； 3.Department of Gastroenterology, the People´s Hospital of Lishui, Lishui 323000, China
  • Online:2013-01-28 Published:2013-02-06

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摘要：

硒结合蛋白1（SBP1）共价结合于硒参与多种细胞内硒的转运。然而硒是一种重要的微量元素，与肿瘤的发生有密切联系，是一种新型抗肿瘤物质。近年来随着对SBP1研究的深入，发现其不但可作为预后指导个性化治疗策略的一种新型生物标志物，而且有望成为肿瘤治疗的新靶点并提高肿瘤细胞的化疗敏感性，作为一种新型抗肿瘤治疗策略应用于临床。该文旨在探讨SBP1的抗肿瘤机制及其作为潜在肿瘤标志物的研究进展，以期指导临床肿瘤个性化治疗，提高患者的预后效果。

关键词: 硒结合蛋白1, 个性化指标, 抗肿瘤, 预测

Abstract:

Selenium binding protein 1 (SBP1) has been shown to bind selenium covalently and is expressed in a variety of tissues and cell lines. Selenium is incorporated into selenoproteins that have a wide range of pleiotropic effects, including its important function in prevention of cancer progression. Recent studies have revealed that SBP1 may not only exert tumor suppressive function, but also become a novel biomarker for predicting prognosis and guiding personalized therapeutic strategies. This paper briefly reviews the studies of SBP1 as a novel biomarker and tumor suppressor in the progression of various cancers.

Key words: selenium binding protein 1, personalized biomarker, anti-tumor, prediction