目的 调查未行治疗的股骨头坏死（ONFH）患者的焦虑和抑郁情绪现状，并分析影响其焦虑和抑郁情绪发生的可能危险因素。方法 2010年1月—12月期间，连续入选235例未行治疗的ONFH患者，采用自制问卷调查患者的人口学信息、生活习惯、疾病史、ONFH专科病史等17项内容；应用Zung制定的焦虑自评量表（SAS）和抑郁自评量表（SDS）测评患者的焦虑和抑郁情绪。采用单因素和多因素方法分析ONFH患者焦虑和抑郁情绪发生的危险因素。结果 共收到有效问卷216份，有效应答率91.91%。ONFH患者的焦虑患病率为20.4%，抑郁患病率为21.8%，焦虑和抑郁共患率为15.7%。单因素分析显示：坏死诱因、坏死病程分期、单双侧坏死、VAS疼痛评分及Harris评分对是否患有焦虑具有统计学意义（P<0.05）；工作状态、坏死诱因、坏死病程、性别、伴随疾病史、单双侧坏死、Harris评分对是否患有抑郁具有统计学意义（P<0.05）。多因素分析显示：影响焦虑发生的危险因素包括单、双侧坏死（OR=3.159, 95%CI: 1.492~6.682）和坏死病程分期（OR=2.443，95%CI：1.417~4.211)；影响抑郁发生的危险因素包括性别（OR=2.941，95%CI：1.476~5.863）、伴随疾病史（OR=4.091，95%CI：1.906～8.779）以及坏死病程分期（OR=4.529，95%CI：2.425～8.458）。结论 未行治疗的ONFH患者伴有焦虑和抑郁情绪的患病率较高，应给予针对性干预措施。

Objective To investigate the prevalence of anxiety and depression in patients with untreated osteonecrosis of the femoral head (ONFH), and explore the potential risk factors. Methods A total of 235 patients with untreated ONFH were consecutively enrolled from January 2010 to December 2010. Seventeen items including demographic characteristics, living habit, history of ONFH and history of other diseases were investigated with self-designed questionnaire. Zung self-rating anxiety scale (SAS) and Zung self-rating depression scale (SDS) were employed to assess the prevalence of anxiety and depression. The risk factors of prevalence of anxiety and depression in patients with ONFH were explored with univariate and multivariate analysis. Results Two hundred and sixteen effective questionnaires were recovered, with the effective rate of 91.91%. The prevalence of anxiety was 20.4%, that of depression was 21.8%, and that of anxiety complicated with depression was 15.7%. Univariate analysis revealed that inducement of necrosis, stage of necrotic severity, unilateral or bilateral necrosis, VAS score and Harris score were risk factors of anxiety (P<0.05), and working state, inducement of necrosis, stage of necrotic severity, gender, history of concomitant diseases, unilateral or bilateral necrosis and Harris score were risk factors of depression (P＜0.05). Multivariate analysis indicated that risk factors of prevalence of anxiety included unilateral or bilateral necrosis of the femoral head (OR=3.159, 95%CI: 1.492-6.682) and stage of necrotic severity (OR=2.443, 95%CI: 1.417-4.211), and risk factors of prevalence of depression included gender (OR=2.941, 95%CI: 1.476-5.863), history of concomitant diseases (OR=4.091, 95%CI: 1.906-8.779) and stage of necrotic severity (OR=4.529, 95%CI: 2.425-8.458). Conclusion Patients with untreated ONFH are associated with higher prevalence of anxiety and depression, and targeted intervention should be performed.