目的 探讨急性脑梗死患者血栓弹力图（TEG）各项参数与血小板聚集率（PAgT）和D-二聚体之间的相关性。方法 选取102例急性脑梗死患者，根据神经功能缺损程度评分标准分为轻度急性脑梗死组（n=41）、中度急性脑梗死组（n=35）和重度急性脑梗死组（n=26）；并以50名健康体检者为对照组。所有研究对象均进行TEG参数（包括R值、K值、α角、MA值、CI值）、PAgT和D-二聚体水平检测。结果 与正常对照组比较，急性脑梗死组患者的R值和K值明显缩短，α角、MA值和CI值明显增大，D-二聚体和PAgT水平明显升高，差异均有统计学意义（P<001）。与中度和轻度脑梗死组比较，重度脑梗死组患者的TEG参数、D-二聚体及PAgT水平差异均有统计学意义（P<0.05）；与轻度脑梗死组比较，中度脑梗死组TEG参数和PAgT水平差异也有统计学意义（P<005），但D-二聚体水平差异无统计学意义（P>0.05）。Pearson相关性分析显示，D-二聚体和PAgT水平与α角、MA值、CI值呈显著正相关，与R值和K值呈显著负相关（均P<0.01）。结论 急性脑梗死患者TEG参数与D-二聚体和PAgT水平存在较强的相关性，TEG在急性脑梗死的诊断、严重程度评价以及高凝状态监测中均具有良好的实用价值。

Objective To investigate the correlation of parameters of thrombelastogram (TEG) with platelet aggregation rate (PAgT) and D-dimer in patients with acute cerebral infarction. Methods One hundred and two patients with acute cerebral infarction were selected, and were divided into mild acute cerebral infarction group (n=41), moderate acute cerebral infarction group (n=35) and severe acute cerebral infarction group (n=26) according to the scores of severity of neurological deficit. Besides, 50 healthy subjects were served as control group. All subjects were examined with the parameters of TEG (including R value, K value, α angle, MA value and CI value), PAgT and D-dimer. Results R-value and K value were significantly smaller, α angle, MA value and CI value were significantly larger and the D-dimer and PAgT levels were significantly higher in patients with acute cerebral infarction than in control group (P<0.01). The parameters of TEG and levels of PAgT and D-dimer in severe acute cerebral infarction group were significantly different from those in mild acute cerebral infarction group and moderate acute cerebral infarction group (P<0.05). The parameters of TEG and PAgT level in moderate acute cerebral infarction group were significantly different from those in mild acute cerebral infarction group (P<0.05), while there was no significant difference in D-dimer level between these two groups (P＞0.05). Pearson correlation analysis revealed that the D-dimer and PAgT levels were positively related to α angle, MA value and CI level (P<0.01), and were negatively related to R-value and K value (P<0.01). Conclusion The parameters of TEG are significantly related to the D-dimer and PAgT levels in patients with acute cerebral infarction. TEG plays a role in the diagnosis of acute cerebral infarction, evaluation of severity of acute cerebral infarction and monitoring of hypercoagulable state.