›› 2011, Vol. 31 ›› Issue (7): 975-.doi: 10.3969/j.issn.1674-8115.2011.07.023

• Original article (Clinical research) • Previous Articles     Next Articles

Effects of liposome prostaglandin E1 on prethrombotic state of patients with severe burn

MA Yu1, YUAN Ke-jian1, YANG Hui-zhong1, QIAO Liang1, WANG Xue-feng2   

  1. 1.Department of Burns, 2.Department of Clinical Blood Transfusion, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2011-07-28 Published:2011-07-27
  • Supported by:

    Shanghai Education Committee Foundation, 06BZ037


Objective To observe the effects of liposome prostaglandin E1 (Lipo-PGE1) on prethrombotic state of patients with severe burn. Methods Twenty-five patients with severe burn whose total burn area≥ 50% total body surface area(TBSA) and/or burn area of degree Ⅲ≥ 20% TBSA were randomly divided into Lipo-PGE1 group (n=15) and control group (n=10). Patients in both groups were given conventional treatment after admission, and those in Lipo-PGE1 group were managed with intravenous injection of Lipo-PGE1 (10 μg once a day for 7 d). Blood samples were collected 1 d, 2 d, 3 d, 7 d and 14 d after burn, and antithrombin antigen (AT:Ag), antithrombin activity (AT:A), protein C activity (PC:A), protein S activity (PS:A), P-selectin (P-sel), soluble fibrin monomer complex (SFMC) and plasmin-α2-antiplasmin complex (PAP) were determined. Thromboelastogram (TEG) was recorded with coagulation analyzer, and the parameters of TEG in Lipo-PGE1 group were compared before and after treatment to assess the coagulation function. ResultsThere was no significant difference in AT:Ag, AT:A, PC:A, PS:A, SFMC and PAP between tow groups at different time points after burn (P>0.05). The expression of P-sel in Lipo-PGE1 group was significantly lower than that in control group 3 d and 7 d after burn (P<0.05). Analysis of TEG parameters revealed that the thromboplastin generation time was (3.77±0.90) min before treatment and (4.98±0.72) min after treatment in Lipo-PGE1 group, and the latter was significantly longer than the former (P<0.05). Conclusion Early application of Lipo-PGE1 after severe burn may effectively improve the prethrombotic state.

Key words: liposome prostaglandin E1, severe burn, prethrombotic state