Abstract:

Objective To compare the clinical efficacy of bladder irrigation with heparin and alkalinized lidocaine for painful bladder syndrome (PBS) under two different temperature (normal temperature and high temperature). Methods Sixty-two female patients newly-diagnosed with PBS were collected. The Interstitial Cystitis Problem Index (ICPI) and Interstitial Cystitis Symptom Index (ICSI) were obtained with O´Leary-sant questionnaire before treatment. Patients were randomly divided into normal temperature group (bladder irrigation with heparin and alkalinized lidocaine under 20 ℃-24 ℃) and high temperature group (bladder irrigation with heparin and alkalinized lidocaine under 37 ℃-40 ℃). ICPI and ICSI were obtained again with O´Leary-sant questionnaire after 8 weeks and 16 weeks of treatment. Results ICPI and ICSI were significantly improved after treatment in two groups (P<0.05). Compared with normal temperature group, ICPI and ICSI in high temperature group were significantly improved 8 weeks after treatment (P<0.05) and 16 weeks after treatment (P<0.001). Three patients (9.38%) in high temperature group experienced strong burning sensation in bladder after first irrigation, but they tolerated after a few times of irrigation. There was no adverse event in normal temperature group. Conclusion The clinical efficacy of bladder irrigation with heparin and alkalinized lidocaine for PBS under high temperature is better than that under normal temperature, with no short-term adverse event.

Key words: painful bladder syndrome, bladder irrigation, temperature