›› 2012, Vol. 32 ›› Issue (5): 661-.doi: 10.3969/j.issn.1674-8115.2012.05.029

• Review • Previous Articles     Next Articles

Research progress of minimum inhibitory concentration detection technology and breakpoint setting for Mycobacterium tuberculosis

ZHANG Chao-bao1,3, WANG Hong-hai2, ZHANG Shu-lin1   

  1. 1.Department of Medical Microbiology, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China;2.State Key Laboratory of Genetic Engineering, Institute of Genetics, Fudan University, Shanghai 200433, China;3.School of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China
  • Online:2012-05-28 Published:2012-06-01
  • Supported by:

    National Major Science and Technology Project of China in the “Eleventh Five-year Plan”, 2009ZX10003-017, 2009ZX10004-313


Tuberculosis is the most common cause of death due to a single infectious agent. The emergence of drug resistance and multidrug resistance is one of the important causes for the epidemics and widespreading of tuberculosis. It is of vital importance to develop the standard and effective detection approach of minimum inhibitory concentration (MIC) and to set up the effective breakpoints in the fields of individualized treatment, detection of drug resistance and drug screening for tuberculosis. The research progress of MIC detection technology and breakpoints setting for Mycobacterium tuberculosis are reviewed in this paper.

Key words: Mycobacterium tuberculosis, minimum inhibitor concentration, breakpoint