›› 2012, Vol. 32 ›› Issue (11): 1404-.doi: 10.3969/j.issn.1674-8115.2012.11.002

• Editorial • Previous Articles     Next Articles

Applications of Mycobacterium tuberculosis genome microevolution

YAO Yu-feng   

  1. Department of Medical Microbiology and Parasitology, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2012-11-28 Published:2012-11-30
  • Supported by:

    National Basic Research Program of China, “973” Program, 2009CB522605;National Natural Science Foundation of China, 31070114;Shanghai Science and Technology Committee Foundation, 12QH1401300


Mycobacterium tuberculosis has been a serious threat to human health globally. In the past 10 years, more achievements on the study of tuberculosis by Chinese scientists have gained worldwide acceptance. However, the diagnosis, treatment, prevention and increasing drug resistance remain to be major problems for tuberculosis control in China. Currently, we have to put efforts on the translation of the tuberculosis basic research and focus on the important clinical issues. Based on the progress of the genome sequencing, it has been found that all genetic events occurring in the Mycobacterium tuberculosis genome evolution play an important role in all aspects including biological properties, pathogenicity and drug resistance. For example, a pyrophosphohydrolase mutation identified by the genome comparison revealed the loss of virulence of the avirulent strain H37Ra. Analysis of Mycobacterium tuberculosis genome microevolution will be beneficial to the diagnosis, treatment and prevention of tuberculosis.

Key words: Mycobacterium tuberculosis, genome microevolution, prevention, diagnosis