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Anti-tumor effect of bisphosphonate drugs

JIN Li-li, SUN Xiao-guang, HUANG Gang   

  1. Department of Nuclear Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2013-09-28 Published:2013-09-29


Bisphosphonate drugs have become important drugs for anti-resorption of bone in clinics since they were found to have inhibitory effect on osteoclasts. Recently, more and more researches propose that bisphosphonate drugs can also affect tumor cells, exhibiting the anti-tumor activity. Especially, the synergy effect of bisphosphonate drugs and anti-tumor drugs makes bisphosphonate drugs play a better anti-tumor role in clinics, improving the quality of life of patients. This paper reviews the anti-tumor effect of bisphosphonate drugs.

Key words: bisphosphonate drugs, anti-tumor, synergy effect