Research progress in anti-tumor effect and mechanism of baicalin

doi:10.3969/j.issn.1674-8115.2021.02.019

Abstract

Abstract:

Baicalin is one of the flavonoids extracted from the root of Chinese herb Scutellariabaicalensis, which is proved to be an effective component in fields of anti-oxidant, anti-inflammation and anti-virus. Based on further studies, baicalin is gradually known to have anti-tumor function. It has an impact on tumor via multiple mechanisms such as induction of tumor cell cycle arrest, induction of apoptosis of tumor cell, inhibition of tumor metastasis and regulation of tumor microenvironment, ranking it a hotspot in Chinese medicine of anti-tumor therapy. This article comprehensively reviews the previous studies on the anti-tumor effect of baicalin, in order to promote understanding of its anti-tumor mechanisms and provide a new insight in anti-tumor therapy.

Key words: baicalin, anti-tumor, tumor apoptosis, tumor metastasis, tumor microenvironment

CLC Number:

R285.6

Meng-ke LIU, Meng-meng JI, Lin CHENG, Jin-yan HUANG, Xiao-jian SUN, Wei-li ZHAO, Li WANG. Research progress in anti-tumor effect and mechanism of baicalin[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(2): 246-250.

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References 36

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