JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2020, Vol. 40 ›› Issue (09): 1288-1293.doi: 10.3969/j.issn.1674-8115.2020.09.020

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Advances in study of regulation of tumor immune inflammatory microenvironment by cancer-associated fibroblasts

ZHAO Wei-guang, LIU Zhi-hong   

  1. Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
  • Online:2020-09-28 Published:2020-11-04
  • Supported by:
    National Natural Science Foundation of China (81672515); Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support (20172019).

Abstract: Cancer-associated fibroblasts (CAFs) are a major population that resides in the tumor microenvironment. Multiple soluble molecules secreted by CAFs remodel the extracellular matrix, thus promoting tumor growth, invasion and metastasis. It is now considered that CAFs play an important role in the regulation of tumor immunity, in which an increasing number of molecular mechanisms of tumor microenvironment remodeling are being discovered. This article reviews the molecular markers of CAFs, the crosstalk between CAFs and tumor cells or immune cells, as well as the progress on therapeutic targeting of CAFs.

Key words: cancer-associated fibroblasts (CAFs), tumor microenvironment, tumor immunity

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