JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (2): 246-250.doi: 10.3969/j.issn.1674-8115.2021.02.019

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Research progress in anti-tumor effect and mechanism of baicalin

Meng-ke LIU(), Meng-meng JI, Lin CHENG, Jin-yan HUANG, Xiao-jian SUN, Wei-li ZHAO, Li WANG()   

  1. Department of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Institute of Hematology; State Key Laboratory of Medical Genomics; National Research Center for Translational Medicine, Shanghai 200025, China
  • Received:2020-01-03 Online:2021-02-28 Published:2021-02-28
  • Contact: Li WANG;
  • Supported by:
    National Natural Science Foundation of China(81520108003);Project of Science and Technology Commission of Shanghai Municipality(16JC1405800);Shanghai Outstanding Youth Medical Talents Training Funding Program;Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20152206);Shanghai Talent Development Fund(2017079);Innovative Research Team of High-Level Local Universities in Shanghai(SSMU-ZLCX20180801)


Baicalin is one of the flavonoids extracted from the root of Chinese herb Scutellariabaicalensis, which is proved to be an effective component in fields of anti-oxidant, anti-inflammation and anti-virus. Based on further studies, baicalin is gradually known to have anti-tumor function. It has an impact on tumor via multiple mechanisms such as induction of tumor cell cycle arrest, induction of apoptosis of tumor cell, inhibition of tumor metastasis and regulation of tumor microenvironment, ranking it a hotspot in Chinese medicine of anti-tumor therapy. This article comprehensively reviews the previous studies on the anti-tumor effect of baicalin, in order to promote understanding of its anti-tumor mechanisms and provide a new insight in anti-tumor therapy.

Key words: baicalin, anti-tumor, tumor apoptosis, tumor metastasis, tumor microenvironment

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