Research progress in the relationship between FOXM1 and neoplasm metabolism

doi:10.3969/j.issn.1674-8115.2024.10.015

Abstract

Abstract:

FOXM1 (forkhead box M1) is an important member of the FOX transcription factor family and plays a critical role in driving the progression of multiple malignancies through its transcriptional regulatory functions. Moreover, the overexpression of FOXM1 is associated with poor prognosis in many types of cancer, as it regulates a variety of biological processes such as gene expression, cell proliferation, invasion, metastasis, and apoptosis. Presently, aberrant metabolic reprogramming has been considered as the major characteristic of cancer development, determining the survival, growth, and proliferation of tumor cells. Accumulating evidence suggests that FOXM1 serves as a "bridge" between metabolism and tumorigenesis. This review aims to provide a comprehensive summary of the research progress in the relationship between FOXM1 and tumor cell metabolism, offering theoretical insights for the development of novel anti-cancer drugs targeting FOXM1.

Key words: forkhead box M1 (FOXM1), tumor, metabolism, inhibitor, tumor microenvironment

CLC Number:

R730.22

LI Yu, JIANG Yifan, TONG Rongliang, CHEN Diyu, WU Jian. Research progress in the relationship between FOXM1 and neoplasm metabolism[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(10): 1323-1329.

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References 53

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