›› 2013, Vol. 33 ›› Issue (1): 114-.doi: 10.3969/j.issn.1674-8115.2013.01.023

• Review • Previous Articles     Next Articles

Research progress on selenium binding protein 1 as a novel tumor biomarker

ZHANG Chen-jing1, PAN Chi2, PAN Wen-sheng1, CHEN Guang-lan3   

  1. 1.Department of Gastroenterology, 2.Department of Oncology, Institute of Cancer Research, Zhejiang University, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; 3.Department of Gastroenterology, the People´s Hospital of Lishui, Lishui 323000, China
  • Online:2013-01-28 Published:2013-02-06


Selenium binding protein 1 (SBP1) has been shown to bind selenium covalently and is expressed in a variety of tissues and cell lines. Selenium is incorporated into selenoproteins that have a wide range of pleiotropic effects, including its important function in prevention of cancer progression. Recent studies have revealed that SBP1 may not only exert tumor suppressive function, but also become a novel biomarker for predicting prognosis and guiding personalized therapeutic strategies. This paper briefly reviews the studies of SBP1 as a novel biomarker and tumor suppressor in the progression of various cancers.

Key words: selenium binding protein 1, personalized biomarker, anti-tumor, prediction