›› 2013, Vol. 33 ›› Issue (1): 114-.doi: 10.3969/j.issn.1674-8115.2013.01.023

• Review • Previous Articles     Next Articles

Research progress on selenium binding protein 1 as a novel tumor biomarker

ZHANG Chen-jing1, PAN Chi2, PAN Wen-sheng1, CHEN Guang-lan3   

  1. 1.Department of Gastroenterology, 2.Department of Oncology, Institute of Cancer Research, Zhejiang University, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China； 3.Department of Gastroenterology, the People´s Hospital of Lishui, Lishui 323000, China
  • Online:2013-01-28 Published:2013-02-06

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Abstract:

Selenium binding protein 1 (SBP1) has been shown to bind selenium covalently and is expressed in a variety of tissues and cell lines. Selenium is incorporated into selenoproteins that have a wide range of pleiotropic effects, including its important function in prevention of cancer progression. Recent studies have revealed that SBP1 may not only exert tumor suppressive function, but also become a novel biomarker for predicting prognosis and guiding personalized therapeutic strategies. This paper briefly reviews the studies of SBP1 as a novel biomarker and tumor suppressor in the progression of various cancers.

Key words: selenium binding protein 1, personalized biomarker, anti-tumor, prediction