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Research progress of genes in lung cancer target therapy and clinical molecular pathological detection

ZHANG Jie   

  1. Department of Pathology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China
  • Online:2013-10-28 Published:2013-10-31


Considerable progress has been made in lung cancer therapy targeted on epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) infusion. The mechanism of genes in lung cancer target therapy, such as EGFR, K-RAS, BRAF, C-MET, EML4-ALK, ROS1 and their relationship with EGFR tyrosine kinase inhibitor (EGFR-TKI) and ALK gene infusion inhibitor are introduced. Meanwhile, important requirements in gene detection are elaborated, including the requirements for specimens, choice of methods and quality control in gene detection of lung cancer.

Key words: lung cancer, target therapy, epidermal growth factor receptor, anaplastic lymphoma kinase, molecular pathology