Abstract:

Objective To compare long-term effects between banding method (Bme) and transverse aortic incision with longitudinal suture method (TLme) in establishment of experimental aortic coarctation models. Methods Forty piglets were randomly divided into Bme group and TLme group (20 in each) to establish aortic coarctation models. Angiographic and histological examinations were carried out 1, 3, and 6 months after model establishment. Another 10 piglets were served as shamoperation group (S group). Results The stenotic vessel models were established successfully. Compared to S group, the diameters of stenotic vessels were significantly smaller in Bme and TLme groups in 1 month (P<0.01), which existed pressure gradients. But the diameter of stenotic vessels in Bme group gradually increased in time of 3 and 6 months and pressure gradients disappeared, which had no significant differences with S group. However, in TLme group, both diameter of stenotic vessels and pressure gradients maintained the same (P<0.01). Conclusion TLme is an effective surgery procedure to establish experimental coarctation model with long-term stability, and the model may be ideal for the study of cardiovascular stents.

Key words: aortic coarctation, surgery procedure, animal model