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Advances of regulation of endoplasmic reticulum stress and HIF-1 to VEGF in diabetic retinopathy

WANG Jing1, ZHU Hong2*, SHI Cai-hong1   

  1. 1.Department of Ophthalmology, the Third People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China; 2.Department of Ophthalmology, the First People′s Hospital, Shanghai Jiao Tong University, Shanghai 200080,  China
  • Online:2014-02-28 Published:2014-03-25
  • Supported by:

    Natural Science Foundation of Shanghai,10ZR1418500


Diabetic retinopathy is one of the most severe microvascular complications of diabetes mellitus, which can lead to irreversible blindness. The main pathological changes of DR are breakdown of blood-retinal barrier and neovascularization. Vascular endothelial growth factor (VEGF) is considered to be the most important intraocular neovascularization factor. Recent researches show that endoplasmic reticulum stress (ERS) and hypoxia-inducible factor-1 (HIF-1) can regulate the expression of VEGF and advance the progress of diabetic retinopathy together. This paper reviews the latest advance of the regulation mechanism of ERS and HIF-1 to VEGF.

Key words: diabetic retinopathy, endoplasmic reticulum stress, hypoxia-inducible factor-1, vascular endothelial growth factor