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Research progresses of major depressive disorder with painful physical symptoms

LI Ning-ning, WU Zhi-guo, FANG Yi-ru   

  1. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2014-04-28 Published:2014-05-13
  • Supported by:
    Medical Guidance Project of Science and Technology Commission of Shanghai Municipality, 134119b0400; National Natural Science Foundation of China,
    91232719); the “12th Five-year Plan” of National Key Technologies R&D Program, 2012BAI01B04; National Key Clinical Disciplines at Shanghai Mental Health Center, 2011-873; Shanghai Mental Health Center Foundation, 2011-YJ-12


Major depressive disorder (MDD) is a kind of extremely complex mental illness. The concurrent pain or other physical symptoms are chief complaints of patients with MDD and may lead to misdiagnosis and treatment delay. So it is clinically essential for the treatment of MDD with concurrent pain symptoms to thoroughly explore the features and related clinical indexes. This paper reviews the research progresses on MDD with pain symptoms.

Key words: major depressive disorder, painful physical symptoms, comorbidity