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Analysis of association between polymorphism of Bcl-2 gene promoter and major depressive disorder and its clinical phenotypes

ZHANG Chen1,3, WU Zhi-guo1, HONG Wu1, WANG Zuo-wei1,4, HU Ying-yan1, CAO Lan1, CHEN Jun1, WANG Yong1, PENG Dai-hui1, LIU Xiao-hua1, YI Zheng-hui1, LU Wei-hong1, YUAN Cheng-mei1, LI Ze-zhi1,5, YU Shun-ying2, WU Yan1, FANG Yi-ru1   

  1. 1.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2.Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 3.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, China; 4.Hongkou District Mental Health Center, Shanghai 200070, China; 5.Department of Neurology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Online:2014-04-28 Published:2014-05-13
  • Supported by:

    National Natural Science Foundation of China, 91232719; the “12th Five-year Plan” of National Key Technologies R&D Program, 2012BAI01B04; National Key Clinical Disciplines at Shanghai Mental Health Center, 2011-873

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Abstract:

Objective To investigate the genetic association between the polymorphism of rs2279115 of Bcl-2 gene promoter and the major depressive disorder (MDD) and its clinical phenotypes among Chinese Han population. Methods Totally 701 MDD patients (the MDD group) who visited the Division of Mood Disorders of Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine from January, 2006 to December, 2012 and 725 healthy control subjects (the control group) were chosen for the study. The clinical phenotypes of patients were determined by the 17 items of Hamilton Depression Rating Scale (HAMD). The peripheral blood samples were collected and the DNA was extracted. Rs2279115 was then genotyped by the TaqMan SNP genotyping assay. Results The differences of frequencies of genotypes and alleles of rs2279115 between the MDD group and control group were not statistically significant (P>0.05). The differences of scores of HAMD, depressive emotion, and general symptom among polymorphous genotypes of rs2279115 were statistically significant (P<0.05). The scores of HAMD, depressive emotion, and general symptom of MDD patients with C/C genotype were significantly higher than those of MDD patients with C/A or A/A genotype. Conclusion The rs2279115 of Bcl-2 gene promoter may be relevant to the clinical symptoms of MDD.

Key words: major depressive disorder, Bcl-2 gene, clinical phenotype