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Advances of calcium/calmodulin-dependent protein kinase Ⅱin major depressive disorder

HUANG Yue-qi, PENG Dai-hui   

  1. Division of Mood Disorder, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2015-09-28 Published:2015-09-30
  • Supported by:

    Fund of Science and Technology Commission of Shanghai Municipality,134119a6200; Shanghai Clinical Center for Mental Disorders,2014; National Key Clinical Disciplines at Shanghai Mental Health Center,Office of Medical Affairs, Ministry of Health, 2011-873


Calcium/calmodulin-dependent protein kinase Ⅱ (CaMKⅡ) plays a crucial role in regulation of synaptic plasticity, glutamate receptors, and phosphorylation of cyclic adenosine phosphate response element binding protein (CREB), which are relevant to the major depressive disorder. This paper reviews possible mechanisms of CaMKⅡ in the process of major depressive disorder.

Key words: major depressive disorder, calcium/calmodulin-dependent protein kinase Ⅱ, synaptic plasticity, glutamate receptors, cyclic adenosine phosphate response element binding protein