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Advances of epidemiology and resistance mechanism of Clostridium difficile infection

LI Zhen, ZHANG Li-hua, DONG Dan-feng, JIANG Cen, PENG Yi-bing   

  1. Department of Clinical Laboratory, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2014-06-28 Published:2014-06-30
  • Supported by:

    Key Basic Research Project of Science and Technology Commission of Shanghai Municipality, 12JC1406100


In recent years, with the dramatic changes in the epidemiology of Clostridium difficile infection (CDI) as well as increases in incidence and severity of the disease, CDI has become a global public health challenge. There have been several outbreaks of CDI in North America and Europe and Clostridium difficile has also become an important pathogenic cause of nosocomial infection in Asia. However, the awareness and surveillance of CDI still remain poor in China. A better knowledge of the epidemiology of CDI and antimicrobial resistance of Clostridium difficile can provide the basis for the prevention and treatment of CDI. This paper reviews the epidemiology and research progresses of resistance mechanism of CDI.

Key words: Clostridium difficile, epidemiology, resistance mechanisms, virulence factors