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Clinicopathologic analysis of peripheral primitive neuroectodermal tumors

QI Qi1, GUO Fei2, WU Shi-wu3   

  1. 1.Department of Histology and Embryology, Bengbu Medical College, Bengbu 233030, China; 2.Department of Radiology, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China; 3.Department of Pathology, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China
  • Online:2015-01-28 Published:2015-01-29
  • Supported by:

    Open Project of Provincial Level Laboratory, Engineering Center, of Bengbu Medical College, BYKL1201; Scientific Research Project (Natural Science) of Bengbu Medical College, BYKY1321

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Abstract:

Objective To investigate the clinicopathologic and immunohistochemical characteristics of peripheral primitive neuroectodermal tumors (pPNET) and its diagnostic criteria. Methods 12 cases of pPNET were observed and analyzed by the HE staining, immmunohistochemistry, and imaging examination. Results 12 patients with pPNET presented progressively growing masses, local pain, and symptoms caused by mass compression. Imaging findings lacked specificity. Under the microscope, tumors consisted of small round cells and Homer-Wright rosettes were observed in 3 cases. Results of immunohistochemistry showed that the positive rate of CD99 was 100% (12/12). Positive rates of NSE and Syn were high, i.e. 92% (11/12) and 75%(9/12), respectively. The positive rate of Vim was 50% (6/12). Conclusion pPNET is a rare, highly malignant sarcoma. Pathological and morphological characteristics and immunohistochemistry labels are helpful for the diagnosis and differential diagnosis of pPNET.

Key words: peripheral primitive neuroectodermal tumors, pathology, tissue, diagnosis