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Analysis of serum apolipoprotein A5 level and related factors for patients with acute coronary syndrome

HUA Sha, ZHAO Jian-rong, QIU Xiao-wei   

  1. Department of Cardiology, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200020
  • Online:2016-04-28 Published:2016-05-26

Abstract:

Objective To analyze the serum apolipoprotein A5 (ApoA5) level and related factors for patients with acute coronary syndrome (ACS). Methods A total of 188 patients who visited the Department of Cardiology of Ruijin Hospital Luwan Branch from July, 2014 to June, 2015 were enrolled and assigned to the ACS group (n=96) and the non-ACS group (control group, n=92) according to the international guideline for ACS diagnosis criteria. Serum ApoA5 level was measured by ELISA and lipid profile, hemogram, creatinine, uric acid, blood glucose, cardiac troponin I (cTn I), and NT-proBNP were also detected. Gensini scores were calculated according to the results of coronary angiography for patients in the ACS group. Correlation analysis was performed based on ApoA5. Results The ApoA5 level in the ACS group was significantly lower than that in the control group (P=0.022). For all samples, ApoA5 was negatively correlated to TG, FFA, and cTn I and positively correlated to HDL and ApoA1. Subgroup analyses showed that ApoA5 was highly and negatively correlated to cTn I and coronary artery Gensini score in the ACS group (P=0.006 9, P=0.014), whereas ApoA5 was not correlated to cTn I in the control group (P=0.079). Conclusion The serum ApoA5 level in ACS patients is significantly lower than that in the patients without ACS and ApoA5 is significantly correlated to myocardial injury and the degree of coronary artery disease.

Key words: coronary atherosclerotic heart disease, apolipoprotein A5, acute coronary syndrome, cardiac troponin I