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Paradigm shift from basic biomedical research to clinical research for achieving top quality clinical research

ZHU Jian-zheng, ZHU Li-jun, CHENG Sha-ni, WANG Hao, DU Ye-ye, PAN Wan-rong, XU Xiao-jing, LIU Hui-jun, ZHOU Shan-sheng, ZHU Hai-ying,MOU Shan   

  1. Human Resource Department, Shanghai Jiao Tong University School of Medicine, Shanghai 200025,China
  • Online:2016-08-29 Published:2016-08-31
  • Supported by:

    Humanities and Social Sciences Innovation Research and Cultivation Project 2016,Shanghai Jiao Tong University School of Medicine,WK1602


Medical research includes basic biomedical research and clinical research. The latter is limited by multiple factors including the failure to appreciate the significance of clinical research, the lack of research funding and specialized teams, the improper evaluation system, the lack of the standardization in data integration and so on. Therefore, the following steps should be taken to strengthen the clinical research. Firstly, the teams of research doctors and clinical scientific researcher have to be constructed, and clinical resources have to be converted into research resources by embracing novel concepts. Secondly, the institutional infrastructure should be transformed to recruit, educate and motivate the excellent researchers and clinicians. Thirdly, the investment should be increased, and the guidance of scientific research funding should be strengthened. Fourthly, the data platform , standardized biobank and unified database system have to be built. Finally, the international collaboration should be strengthened, and the building of multicenter research network for randomized controlled trials should be speed up.

Key words: research paradigm, basic biomedical research, clinical research