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Clinical and prognostic analyses of non-Hodgkin lymphoma combined with hemophagocytic syndrome

XIAO Hui-fang1,2, HAO Jie3*, ZHAO Wei-li1, WANG li1   

  1. 1. Department of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2 Department of Hematology, First Quan-zhou Hospital, Fujian Medical University, Quan Zhou362000, China; 3. Department of Hematology, North Station Hospital of Shanghai, Shanghai 200070, China
  • Online:2016-08-29 Published:2016-08-31
  • Supported by:

    Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support,201522060;Project of Shanghai Municipal Science and Technology Commission, 14430723400, 14140903100


Objective · To compare the clinical features and prognosis between non-Hodgkin lymphoma (NHL) patients with and without hemophagocytic syndrome (HPS). Methods · A retrospective analysis was performed for 33 NHL patients with HPS (the HPS group) and 76 NHL patients without HPS (the control group) admitted from January 2006 to May 2014. Survival analysis was conducted with Kaplan-Meier method and univariate and multivariate analyses were carried out by using a COX regression model for factors that might affect the survival of patients. Results · The NHL patients with HPS were likely to start with fever. Most bone marrow samples (29/33) had elevated serum ferritin, triglyceride, total bilirubin, and lactate dehydrogenase (LDH) and hemophagocytes could be found in these samples. The NHL patients with HPS had late disease stage, poor physical ability, and severe disease status and their prognosis was poorer compared with controls (P=0.000). Failure to achieve complete remission and the combination of HPS were independent risk factors for poor prognosis of NHL patients. Conclusion · The NHL patients with HPS have severe disease status and poor prognosis.

Key words: non-Hodgkin lymphoma, hemophagocytic syndrome, clinical features, prognosis