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Progress of research on long noncoding RNA in breast cancer

YAN Ning-ning1, 2, HE Zhan-qiang3*, XU Hai-yan1, ZHANG Feng-chun1, 2   

  1. 1.Department of Oncology, Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou 215021, China; 2.Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 3.Department of Emergency, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 2000127, China
  • Online:2017-01-28 Published:2017-01-19
  • Supported by:

    Suzhou Science and Technology Project, SYS201062，SYS201308，SYS201404; National Natural Science Foundation of China, 81301858

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Abstract:

With the expanding of human genome project and advent of post-genomic era, understanding of genome structure and function is more and more deepening. Increasing noncoding RNAs (ncRNAs) were discovered, among which longer than 200 nucleotides termed as long non-coding RNAs (LncRNAs) are involved in the pathophysiological processes including proliferation, differentiation, development, and apoptosis, becoming the new hot spots of cancer research. Breast cancer is the most common malignant tumor among women. In this article, the conception of LncRNAs and its role in occurrence, development and prognosis of breast cancer is reviewed.

Key words: breast cancer, noncoding RNA, long noncoding RNA