›› 2017, Vol. 37 ›› Issue (6): 769-.doi: 10.3969/j.issn.1674-8115.2017.06.010

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Correlation of serum S100B protein with depressive episode of bipolar disorder and its prognosis

ZHANG Zai-fu1, YANG Fan1, WANG Wei-ping1, SHI Bo1, ZHAO Jun-xiong1, LÜ Wang-qiang1, YU Yue-guo1, JIA Yu-ping2, ZHANG Chen1, 2   

  1. 1. Jinhua Second Hospital, Jinhua 321016, China; 2. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2017-06-28 Published:2017-07-05
  • Supported by:

    National Natural Science Foundation of China, 81471358; Key Project of Jinhua Science and Technology Beaureu, 2015-3-022; Project of Shanghai Municipal Science and Technology Commission, 14411969000; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152530; Foundation of Shanghai Municipal Commission of Health and Family Planning, 201540029


Objective · To explore the correlation of serum S100B protein with depressive episode of bipolar disorder (BD) and its prognosis.  Methods · Based on BD criteria of Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM- Ⅳ ), 80 patients with depressive episode of BD (case group) and 42 healthy controls (control group) were enrolled. Patients were randomly assigned into quetiapine group who were treated with lithium and quetiapine and modified electroconvulsive therapy (MECT) group who received lithium and MECT. The serum S100B level and Hamilton Rating Scale for Depression (HAMD) were assayed before and after 4-week treatment.  Results · The serum S100B levels before treatment in patients with depressive episode of BD were significantly higher than those in healthy controls (P=0.000). The levels of S100B in both drug and MECT groups decreased after 4-week treatment. The HAMD score after treatment significantly decreased than that before treatment (P=0.000). Pearson correlation analysis showed that the change of S100B level was positively correlated with the change of HAMD score before and after treatment in case group (r=0.33, P=0.013).  Conclusion · S100B may be associated with depressive episode of BD and its prognosis.

Key words:  bipolar disorder, depressive episode, S100B, modified electroconvulsive therapy