Abstract:

 Objective · To explore influencing factors associated with the hydration status in peritoneal dialysis (PD) patients.  Methods · Eligible PD patients treated in Renji Hospital affiliated to Shanghai Jiao Tong University School of Medicine from September 2016 to January 2017 were enrolled. Demographic data of patients were collected and biochemical indexes were measured. Their peritoneal transport characteristics and dialysis adequacy were evaluated. Hydration status index overhydration (OH) value was measured with bioimpedance spectroscopy. Multivariate linear regression was used to analyze the independent factors associated with the OH.  Results · A total of 147 PD patients with a median age of 58.52 years and a median PD duration of 43.03 months were enrolled. Of them, 90 (61.2%) were male, 21(14.3%) were accompanied by diabetes mellitus, and 107 (72.8%) were overhydrated (OH>1.1L). Compared to those with normal hydration status (OH ≤ 1.1 L), the overhydrated patients had higher proportion of diabetes,
 BSA, Charlson comorbidity score, brain natriuretic peptide (BNP), 4 h D/Pcr, and 24 h dialysate protein, and lower tKt/V, serum albumin than the normal hydrated patients (all P<0.05). Multivariate linear regression showed that comorbid diabetes mellitus (P=0.000), higher 4h D/Pcr (P=0.000), and lower serum albumin level (P=0.001) were independent relevant factors for the increase of OH.  Conclusion · Overhydration is common in PD patients. Comorbid diabetes mellitus, higher 4 h D/Pcr, and lower serum albumin are independent relevant factors for the hydration status in
 PD patients.

Key words:  peritoneal dialysis, overhydration, bioimpedance spectroscopy