Abstract: Objective · To investigate the role of common clinical indicators in volume assessments of peritoneal dialysis (PD) patients. Methods · Eligible PD patients in Renji Hospital, Shanghai Jiao Tong University School of Medicine Nov. 2016 to Nov. 2017 were enrolled. Demographic data of patients were collected and clinical parameters were measured. Hydration status index overhydration (OH) was measuredbioimpedance spectroscopy, and the association between clinical indicators and OH was analyzed. Results · A total of 200 PD patients aged 56.3±13.8 years with median PD duration of 46.6 months were enrolled in the study. Among them, 117 (58.5%) patients were males and 42 (21.0%) patients were diabetic. 141 (70.5%) patients in the present study were overhydrated (OH>1.1 L). Compared to those with normal hydration, the overhydrated patients had higher blood pressure, more obvious edema and higher brain natriuretic peptide (BNP) level (P<0.05). In the overhydrated patients, 51 (36.2%) patients had normal blood pressure, 67 (47.5%) patients had no edema and 46 (32.6%) patients had BNP less than 100 pg/mL. In the normal hydrated patients, 20 (33.9%) patients had high blood pressure, 8 (13.6%) patients had edema and 1 (1.7%) patient had BNP higher than 400 pg/mL. Systolic pressure and BNPlevel were both correlated with OH positively (systolic pressure r0.361, P0.001; BNP r0.615, P0.000).The patients who had more obviousedema also had higher OH(P0.000). Conclusion · Blood pressure, edema and BNP are closely associated with the hydration status, but only one of these clinical indicators can not accurately reflect the hydration status in all PD patients. Combination of different indicatorsmay be useful in evaluation of hydration status in PD patients.

Key words: peritoneal dialysis (PD), hydrationstatus, bioimpedance spectroscopy, bloodpressure, edema, brain natriuretic peptide (BNP)