›› 2018, Vol. 38 ›› Issue (8): 917-.doi: 10.3969/j.issn.1674-8115.2018.08.010

• Original article (Clinical research) • Previous Articles     Next Articles

Characteristic of brain microbleeds in Alzheimers disease

WU Yi-na1, 2, ZHUANG Hui-xiang3, LI Fan3, LIU Yuan-yuan1, 2, YAN Feng1, 2, SHI Yan-chen1, 2, WANG Jing-hua1, 2, ZHANG Jian-ye1, LIU Man-hua3, WANG Jinhong1, XIAO Shi-fu1, 2, WANG Tao1, 2   

  1. 1. Geriatric Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. Alzheimer Disease and Related Disorders Center of Shanghai Jiao Tong University, Shanghai 200025, China; 3. Department of Instrument Science and Engineering, Shanghai Jiao Tong University School of Electronic Information and Electrical Engineering, Shanghai 200240, China
  • Online:2018-08-28 Published:2018-09-11
  • Supported by:
    National Natural Science Foundation of China, 81571298; Shanghai Pujiang Plan, 17PJD038; Shanghai Health System Excellent Talent Training Program (Excellent Subject Leader), 2017BR054; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Support, 20172029; Collaborative Innovation Center for Translational Medicine of Shanghai Jiao Tong University School of Medicine Project, TM201728

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Abstract: Objective · Toevaluatethedifferencesof brain microbleedsamongAlzheimer′s disease(AD),amnesia mild cognitiveimpairment (aMCI)and normal control (NC). Methods · Eighteen AD patients, 28 aMCI patients and 30 age-matched NC were recruited in the study. The location and number of microbleeds was recorded in the brain according to the susceptibility-weighted images. The bilateral frontal lobe, parietal lobe, occipital lobe, temporal lobe, and thalamus were manually mapped on 3D-MR imaging. The number of cases with microbleeds and the number of microbleeds in each lobe were calculated and compared among three groups using the chi-square test and ANOVA. Results · Significant differences on case number with microbleeds were found betweenAD group and NC group in the frontal lobe (P0.005), the temporal lobe (P0.005) and whole brain (P0.004), and between aMCI group and NC group in the frontal lobe (P0.048). It also showed significant differences among three groups in the frontal lobe (P0.006), the temporal lobe (P0.006) and whole brain (P0.016). For the microbleeds counts, significant differences were found betweenAD group and NC group in the frontal lobe (P0.004) and the temporal lobe (P0.049), and between AD group and NC group in the frontal lobe (P0.044). It also had significant differences among three groups in the frontal lobe (P0.016), the temporal lobe (P0.038) and whole brain (P0.048). Conclusion · The AD group has more significantmicrobleeds in frontal and parietal lobes incomparison toNC group.The quantization of cerebral microbleedsmay be apotential biomarker for AD diagnosis.

Key words: mild cognitive impairment (MCI), Alzheimer&, prime, sdisease, susceptibility-weighted image (SWI), brainmicrobleed

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