›› 2017, Vol. 37 ›› Issue (9): 1261-.doi: 10.3969/j.issn.1674-8115.2017.09.012

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Effects of ACE2/Apelin signaling on vascular autophagy regulation and  hypertension pathogenesis#br#

ZHANG Yan, CHENG Yu-wen, ZHONG Jiu-chang   

  1. Shanghai Institute of Hypertension; State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2017-09-28 Published:2017-10-10
  • Supported by:
    National Natural Science Foundation of China, 81370362, 81770253; National Major Research Plan Training Program, 91339108; National Basic Research Program of China, 2014CB542300; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152509

Abstract:  Autophagy provides protective effects on the maintenance of normal vascular structure and function. However, an overactivation of autophagy contributes to the pathogenesis of hypertension and other vascular diseases. The imbalance of vascular autophagy is involved in the occurrence and development of hypertensive vascular remodeling and injury, which is closely related to abnormal expression or activity of ACE2/Apelin signaling. This review will focus on the latest advancement and regulatory roles of ACE2/Apelin signaling in vascular autophagy and the pathogenesis of hypertension.

Key words: hypertension, renin-angiotensin system, autophagy, angiotensin Ⅱ