›› 2018, Vol. 38 ›› Issue (6): 632-.doi: 10.3969/j.issn.1674-8115.2018.06.008

• Original article (Clinical research) • Previous Articles     Next Articles

Analysis of liver function, serum lipid and blood routine in patients with differentiated thyroid cancer before radioactive iodine treatment

XU Fei, TANG Ling-lin, YUAN Hong, SONG Shao-li, HUANG Gang   

  1. Department of Nuclear Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2018-06-28 Published:2018-07-03
  • Supported by:
    National Natural Science Foundation of China, 81771861, 81471708; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Support, 20172010

Abstract: Objective · To investigate the effect of temporary hypothyroidism state to liver function, serum lipid and blood routine in patients with differentiated thyroid cancer (DTC) prepared for radioactive iodine treatment. Methods · A total of 182 patients with DTC undergoing radical operation of thyroid cancer and radioactive iodine treatment were collected. All these patients were divided into 3 groupsage: 26 in young group (<30 years), 112 in middle-aged group (30-54 years) and 44 in elderly group (≥55 years). Indicators of liver function, blood lipids and blood routine were compared before and after operation, among groups as well. Results · Patients under hypothyroidism state had significantly elevations in ALT, AST, LDH and serum bile acid, but a nodecrease of serum bilirubin (all P<0.05). Meanwhile they had remarkable elevations in triglyceride, cholesterol, LDL and HDL (all P<0.05). In the young group before thyroid hypothyroidism treatment, the elevation of ALT, AST, LDH and serum bile acid were more significant than those of the middle-aged and elderly patients (all P<0.05). Conclusion · The temporary hypothyroidism state of differentiated thyroid cancer patients could elevate liver enzymes as well as dyslipidemia.

Key words: differentiated thyroid cancer, iodine radioisotopes, liver dysfunction, hypothyroidism

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