JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (9): 1215-1221.doi: 10.3969/j.issn.1674-8115.2021.09.012

• Clinical research • Previous Articles    

Association study of variation of glucagon-like peptide-1 receptor gene rs3765467 and type 2 diabetes mellitus

Jing-jing ZHANG1(), Chao-yu ZHU2, Yuan-yuan XIAO2, Fu-song JIANG2, Qing-ge GAO2, Yun-yun FANG2, Li WEI2()   

  1. 1.Department of Biology, Shanghai Ocean University, College of Fisheries and Life Science, Shanghai 201306, China
    2.Department of Endocrinology and Metabolism, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Received:2021-04-13 Online:2021-08-24 Published:2021-08-24
  • Contact: Li WEI;
  • Supported by:
    Natural Science Foundation of Shanghai(20ZR1442500);Research Joint Project of Pudong New Area Health and Family Planning(PW2018D-14)

Abstract: Objective

·To investigate the association of single nucleotide polymorphisms (SNPs) in the glucagon-like peptide-1 receptor (GLP-1R) gene with type 2 diabetes mellitus (T2DM).


·A total of 318 Han patients with T2DM and 145 non-diabetic controls in Shanghai were enrolled.The polymorphisms of GLP-1R gene were detected with multiplex PCR-High throughput resequencing. Differences in frequencies of genotypes and alleles, as well as other clinical variables between the two groups were analyzed.


·Twenty three SNPs were detected. The polymorphism of GLP-1R rs3765467 (G/A) was significantly associated with T2DM (P=0.005). Compared with GG genotype carriers, GA+AA genotype carriers had a lower risk of T2DM (OR=0.502, 95% CI 0.305-0.829, P=0.007), while GA+AA genotype carriers had a significantly lower risk of T2DM (OR=0.403, 95% CI 0.186-0.871, P=0.021) in the male population. Association analysis of clinical feature showed that the glycosylated albumin level of GA+AA genotype carriers was lower than that of GG genotype carriers (P=0.048).


·GLP-1R rs3765467 polymorphism is associated with T2DM in Shanghai Han population. Minor allele A contributes to maintaining blood glucose homeostasis and is a protective factor for T2DM, especially in men.

Key words: glucagon-like peptide-1 receptor (GLP-1R), single nucleotide polymorphism (SNP), rs3765467, type 2 diabetes mellitus (T2DM)

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