JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (11): 1405-1411.doi: 10.3969/j.issn.1674-8115.2021.11.001
• Disorders of sex development in children • Next Articles
Lin-lin LI1(), Shao-hua HU2, Xiao-qin YIN1, Pin LI1()
Online:
2021-11-28
Published:
2021-10-29
Contact:
Pin LI
E-mail:lilinlin1208@126.com;lipin21@126.com
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Lin-lin LI, Shao-hua HU, Xiao-qin YIN, Pin LI. Changes of serum unsaturated free fatty acid profiles in girls with idiopathic central precocious puberty and their correlations with body mass index and sex hormones[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(11): 1405-1411.
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URL: https://xuebao.shsmu.edu.cn/EN/10.3969/j.issn.1674-8115.2021.11.001
Item | Control group (n=46) | ICPP group (n=56) |
---|---|---|
Age/year | 8.23±1.45 | 8.28±0.59 |
Height/cm | 124.10±9.81 | 134.63±5.84① |
Weight/kg | 24.64±5.46 | 31.15±4.70① |
BMI/(kg·m-2) | 15.92±1.88 | 17.12±1.84② |
BMI SDS | -0.34±0.96 | 0.28±0.95② |
Tab 1 Comparison of general clinical data of the two groups (x±s)
Item | Control group (n=46) | ICPP group (n=56) |
---|---|---|
Age/year | 8.23±1.45 | 8.28±0.59 |
Height/cm | 124.10±9.81 | 134.63±5.84① |
Weight/kg | 24.64±5.46 | 31.15±4.70① |
BMI/(kg·m-2) | 15.92±1.88 | 17.12±1.84② |
BMI SDS | -0.34±0.96 | 0.28±0.95② |
FFA | Control group | ICPP group | ||
---|---|---|---|---|
r value | P value | r value | P value | |
C16:1 | -0.012 | 0.935 | -0.247 | 0.066 |
C18:1 | 0.062 | 0.682 | -0.092 | 0.499 |
C20:1 | 0.077 | 0.610 | -0.128 | 0.347 |
LA | -0.022 | 0.885 | -0.138 | 0.310 |
GLA | 0.250 | 0.093 | -0.192 | 0.156 |
AA | -0.102 | 0.501 | -0.147 | 0.279 |
n-6DPA | -0.095 | 0.531 | -0.091 | 0.506 |
ALA | -0.050 | 0.743 | -0.155 | 0.254 |
EPA | 0.131 | 0.384 | -0.074 | 0.589 |
n-3DPA | 0.107 | 0.477 | -0.103 | 0.451 |
DHA | -0.158 | 0.296 | -0.185 | 0.172 |
Tn-6 | -0.048 | 0.753 | -0.133 | 0.327 |
Tn-3 | -0.057 | 0.704 | -0.194 | 0.153 |
Tn-6/Tn-3 | 0.052 | 0.729 | 0.087 | 0.524 |
Tab 2 Correlation of unsaturated free fatty acid profiles and BMI in the two groups
FFA | Control group | ICPP group | ||
---|---|---|---|---|
r value | P value | r value | P value | |
C16:1 | -0.012 | 0.935 | -0.247 | 0.066 |
C18:1 | 0.062 | 0.682 | -0.092 | 0.499 |
C20:1 | 0.077 | 0.610 | -0.128 | 0.347 |
LA | -0.022 | 0.885 | -0.138 | 0.310 |
GLA | 0.250 | 0.093 | -0.192 | 0.156 |
AA | -0.102 | 0.501 | -0.147 | 0.279 |
n-6DPA | -0.095 | 0.531 | -0.091 | 0.506 |
ALA | -0.050 | 0.743 | -0.155 | 0.254 |
EPA | 0.131 | 0.384 | -0.074 | 0.589 |
n-3DPA | 0.107 | 0.477 | -0.103 | 0.451 |
DHA | -0.158 | 0.296 | -0.185 | 0.172 |
Tn-6 | -0.048 | 0.753 | -0.133 | 0.327 |
Tn-3 | -0.057 | 0.704 | -0.194 | 0.153 |
Tn-6/Tn-3 | 0.052 | 0.729 | 0.087 | 0.524 |
FFA | LHB | FSHB | LHB/FSHB | LHP | FSHP | LHP/FSHP | E2 | SHBG | IGF-1 |
---|---|---|---|---|---|---|---|---|---|
C16:1 | 0.098 | -0.066 | 0.230 | 0.219 | -0.001 | 0.220 | -0.032 | 0.037 | 0.095 |
C18:1 | 0.068 | 0.001 | 0.226 | 0.281⑩ | 0.089 | 0.214 | -0.032 | 0.036 | 0.189 |
C20:1 | 0.140 | 0.049 | 0.206 | 0.290⑪ | 0.055 | 0.214 | 0.039 | 0.105 | 0.180 |
LA | -0.001 | -0.035 | 0.170 | 0.311⑫ | 0.143 | 0.179 | -0.101 | -0.022 | 0.182 |
GLA | -0.088 | -0.175 | 0.089 | 0.343⑬ | 0.142 | 0.239 | -0.209 | 0.046 | 0.108 |
AA | -0.231 | -0.172 | -0.204 | -0.064 | 0.073 | -0.146 | -0.198 | -0.166 | 0.007 |
n-6DPA | -0.135 | -0.160 | -0.109 | -0.021 | 0.079 | -0.210 | -0.223 | -0.114 | 0.049 |
ALA | -0.005 | -0.100 | 0.194 | 0.348⑭ | 0.066 | 0.315⑯ | -0.087 | -0.038 | 0.195 |
EPA | -0.268① | -0.309③ | -0.323⑧ | -0.137 | -0.007 | -0.187 | -0.406⑦ | -0.163 | -0.103 |
n-3DPA | -0.239 | -0.395④ | -0.219 | 0.121 | 0.018 | 0.072 | -0.426⑰ | -0.158 | 0.195 |
DHA | -0.273② | -0.356⑤ | -0.252 | -0.074 | -0.018 | -0.152 | -0.294⑱ | -0.097 | -0.099 |
Tn-6 | -0.047 | -0.071 | 0.113 | 0.274⑮ | 0.148 | 0.122 | -0.131 | -0.050 | 0.166 |
Tn-3 | -0.209 | -0.333⑥ | -0.081 | 0.164 | 0.031 | 0.090 | -0.338⑲ | -0.113 | 0.059 |
Tn-6/Tn-3 | 0.228 | 0.410⑦ | 0.312⑨ | 0.124 | 0.169 | 0.004 | 0.216 | 0.057 | 0.208 |
Tab 3 Correlation between serum unsaturated free fatty acid profiles and sex hormones in ICPP girls (r)
FFA | LHB | FSHB | LHB/FSHB | LHP | FSHP | LHP/FSHP | E2 | SHBG | IGF-1 |
---|---|---|---|---|---|---|---|---|---|
C16:1 | 0.098 | -0.066 | 0.230 | 0.219 | -0.001 | 0.220 | -0.032 | 0.037 | 0.095 |
C18:1 | 0.068 | 0.001 | 0.226 | 0.281⑩ | 0.089 | 0.214 | -0.032 | 0.036 | 0.189 |
C20:1 | 0.140 | 0.049 | 0.206 | 0.290⑪ | 0.055 | 0.214 | 0.039 | 0.105 | 0.180 |
LA | -0.001 | -0.035 | 0.170 | 0.311⑫ | 0.143 | 0.179 | -0.101 | -0.022 | 0.182 |
GLA | -0.088 | -0.175 | 0.089 | 0.343⑬ | 0.142 | 0.239 | -0.209 | 0.046 | 0.108 |
AA | -0.231 | -0.172 | -0.204 | -0.064 | 0.073 | -0.146 | -0.198 | -0.166 | 0.007 |
n-6DPA | -0.135 | -0.160 | -0.109 | -0.021 | 0.079 | -0.210 | -0.223 | -0.114 | 0.049 |
ALA | -0.005 | -0.100 | 0.194 | 0.348⑭ | 0.066 | 0.315⑯ | -0.087 | -0.038 | 0.195 |
EPA | -0.268① | -0.309③ | -0.323⑧ | -0.137 | -0.007 | -0.187 | -0.406⑦ | -0.163 | -0.103 |
n-3DPA | -0.239 | -0.395④ | -0.219 | 0.121 | 0.018 | 0.072 | -0.426⑰ | -0.158 | 0.195 |
DHA | -0.273② | -0.356⑤ | -0.252 | -0.074 | -0.018 | -0.152 | -0.294⑱ | -0.097 | -0.099 |
Tn-6 | -0.047 | -0.071 | 0.113 | 0.274⑮ | 0.148 | 0.122 | -0.131 | -0.050 | 0.166 |
Tn-3 | -0.209 | -0.333⑥ | -0.081 | 0.164 | 0.031 | 0.090 | -0.338⑲ | -0.113 | 0.059 |
Tn-6/Tn-3 | 0.228 | 0.410⑦ | 0.312⑨ | 0.124 | 0.169 | 0.004 | 0.216 | 0.057 | 0.208 |
Dependent variable | Independent variable | Constant | β | SE | Normalization coefficient β | t value | P value | 95%CI for β |
---|---|---|---|---|---|---|---|---|
LHB | DHA | 1.306 | -0.027 | 0.013 | -0.273 | -2.046 | 0.046 | -0.054‒0.001 |
FSHB | Tn-6/Tn-3 | 2.695 | 0.328 | 0.118 | 0.337 | 2.779 | 0.008 | 0.091‒0.564 |
n-3DPA | -0.606 | 0.232 | -0.317 | -2.618 | 0.011 | -1.071‒-0.142 | ||
LHB/FSHB | EPA | 0.278 | -0.021 | 0.008 | -0.323 | -2.463 | 0.017 | -0.038‒-0.004 |
LHP | ALA | 10.645 | 0.644 | 0.236 | 0.348 | 2.726 | 0.009 | 0.170-1.118 |
LHP/FSHP | ALA | 1.161 | 0.033 | 0.014 | 0.315 | 2.440 | 0.018 | 0.006-0.060 |
E2 | n-3DPA | 175.136 | -27.353 | 9.960 | -0.350 | -2.746 | 0.008 | -47.323‒-7.384 |
Tab 4 Multiple regression analysis of serum unsaturated free fatty acid profiles and sex hormones in ICPP girls
Dependent variable | Independent variable | Constant | β | SE | Normalization coefficient β | t value | P value | 95%CI for β |
---|---|---|---|---|---|---|---|---|
LHB | DHA | 1.306 | -0.027 | 0.013 | -0.273 | -2.046 | 0.046 | -0.054‒0.001 |
FSHB | Tn-6/Tn-3 | 2.695 | 0.328 | 0.118 | 0.337 | 2.779 | 0.008 | 0.091‒0.564 |
n-3DPA | -0.606 | 0.232 | -0.317 | -2.618 | 0.011 | -1.071‒-0.142 | ||
LHB/FSHB | EPA | 0.278 | -0.021 | 0.008 | -0.323 | -2.463 | 0.017 | -0.038‒-0.004 |
LHP | ALA | 10.645 | 0.644 | 0.236 | 0.348 | 2.726 | 0.009 | 0.170-1.118 |
LHP/FSHP | ALA | 1.161 | 0.033 | 0.014 | 0.315 | 2.440 | 0.018 | 0.006-0.060 |
E2 | n-3DPA | 175.136 | -27.353 | 9.960 | -0.350 | -2.746 | 0.008 | -47.323‒-7.384 |
FFA | Pre-treatment (n=48) | Post-treatment (n=48) | Z | P |
---|---|---|---|---|
C16:1 | 42.18 (28.54, 52.10) | 10.53 (5.90, 17.07)① | -5.672 | 0.000 |
C18:1 | 350.09 (267.91, 451.32) | 168.24 (105.08, 223.83)① | -4.810 | 0.000 |
C20:1 | 3.14 (2.26, 4.05) | 1.45 (1.02, 2.12)① | -4.523 | 0.000 |
LA | 247.00 (190.12, 315.11) | 199.65 (146.69, 271.74)② | -2.482 | 0.013 |
GLA | 4.51 (3.66, 6.10) | 3.26 (1.85, 4.94)② | -2.482 | 0.013 |
AA | 26.27 (20.22, 36.80) | 41.98 (35.19, 54.05)③ | -3.426 | 0.001 |
n-6DPA | 1.72 (1.21, 2.70) | 1.96 (1.54, 2.88) | -0.882 | 0.378 |
ALA | 17.45 (12.59, 21.96) | 12.84 (7.08, 19.23)④ | -2.144 | 0.032 |
EPA | 1.71 (0.98, 3.00) | 2.58 (1.89, 4.38)① | -4.127 | 0.000 |
n-3DPA | 2.41 (1.64, 3.39) | 2.05 (1.70, 2.59) | -1.698 | 0.090 |
DHA | 12.67 (9.24, 20.22) | 15.70 (12.65, 20.49)⑤ | -2.236 | 0.025 |
Tn-6 | 294.60 (216.96, 365.63) | 248.04 (186.72, 326.19) | -1.856 | 0.063 |
Tn-3 | 35.55 (28.25, 47.23) | 35.75 (27.32, 43.96) | -0.400 | 0.689 |
Tn-6/Tn-3 | 7.69 (6.52, 9.60) | 6.86 (6.10, 7.68)① | -3.787 | 0.000 |
Tab 5 Changes of serum unsaturated free fatty acid profiles in ICPP girls before and after GnRHa treatment [μmol·L-1, M(Q1,Q3)]
FFA | Pre-treatment (n=48) | Post-treatment (n=48) | Z | P |
---|---|---|---|---|
C16:1 | 42.18 (28.54, 52.10) | 10.53 (5.90, 17.07)① | -5.672 | 0.000 |
C18:1 | 350.09 (267.91, 451.32) | 168.24 (105.08, 223.83)① | -4.810 | 0.000 |
C20:1 | 3.14 (2.26, 4.05) | 1.45 (1.02, 2.12)① | -4.523 | 0.000 |
LA | 247.00 (190.12, 315.11) | 199.65 (146.69, 271.74)② | -2.482 | 0.013 |
GLA | 4.51 (3.66, 6.10) | 3.26 (1.85, 4.94)② | -2.482 | 0.013 |
AA | 26.27 (20.22, 36.80) | 41.98 (35.19, 54.05)③ | -3.426 | 0.001 |
n-6DPA | 1.72 (1.21, 2.70) | 1.96 (1.54, 2.88) | -0.882 | 0.378 |
ALA | 17.45 (12.59, 21.96) | 12.84 (7.08, 19.23)④ | -2.144 | 0.032 |
EPA | 1.71 (0.98, 3.00) | 2.58 (1.89, 4.38)① | -4.127 | 0.000 |
n-3DPA | 2.41 (1.64, 3.39) | 2.05 (1.70, 2.59) | -1.698 | 0.090 |
DHA | 12.67 (9.24, 20.22) | 15.70 (12.65, 20.49)⑤ | -2.236 | 0.025 |
Tn-6 | 294.60 (216.96, 365.63) | 248.04 (186.72, 326.19) | -1.856 | 0.063 |
Tn-3 | 35.55 (28.25, 47.23) | 35.75 (27.32, 43.96) | -0.400 | 0.689 |
Tn-6/Tn-3 | 7.69 (6.52, 9.60) | 6.86 (6.10, 7.68)① | -3.787 | 0.000 |
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