Abstract:

Objective ·To retrieve and evaluate evidence related to weight management during endocrine therapy for prostate cancer patients, and summarize the best evidence available. Methods ·The PIPOST model was adopted to construct evidence-based questions. Following the “6S” model of evidence resources, a systematic computer-based search was conducted to retrieve relevant evidence on weight management during prostate cancer endocrine therapy from various databases and websites, including Guidelines International Network, BMJ Best Practice, UpToDate, JBI Evidence-Based Healthcare Center Database, American Guidelines Network, Medlive, Cochrane Library, PubMed, CINAHL, Web of Science, Embase, CNKI, Chinese Biomedical Literature Database, Wanfang Database, and VIP Database, as well as the websites of the American Urological Association, European Urological Association, and Urological Branch of Chinese Medical Association. The evidence retrieved included guidelines, clinical decisions, recommended practices, expert consensuses, evidence summaries, systematic reviews, and original studies. The search period spanned from database establishment to December 2023. Two researchers independently evaluated the quality of the included literature. The included articles were read one by one and summarized according to themes. Priority was given to high-level, high-quality, and newly published authoritative literature during evidence screening and extraction. The included and extracted evidence was uniformly classified into levels 1‒5 according to the JBI evidence pre-classification and evidence recommendation level system, and the evidence recommendations were divided into strongly recommended (Grade A) and weakly recommended (Grade B). Results ·A total of 12 articles were retrieved, consisting of 4 guidelines, 3 expert consensuses, 2 evidence summaries, 2 randomized controlled trials, and 1 quasi-experimental study. All 12 articles were rated as high quality and were included. The best evidence was summarized into 8 aspects: weight management assessment and monitoring, multidisciplinary collaboration, personalized support, family involvement strategies, nutrition management strategies, exercise management strategies, health education, and follow-up management. Conclusion ·The best evidence for weight management during endocrine therapy for prostate cancer is summarized into eight aspects. In clinical application, specific clinical situations and patient characteristics should also be considered to improve the effectiveness of clinical interventions and the quality of care.

Key words: prostate neoplasm, endocrinotherapy, weight management, evidence-based nursing, evidence summary