Abstract:

Objective To evaluate anti-Müllerian hormone (AMH) in prediction of poor ovarian response to controlled ovarian hyperstimulation. Methods The serum levels of basal follicle-stimulating hormone (bFSH), basal luteinizing hormone (bLH), basal estradiol (bE2), bilateral antral follicle count (AFC) and AMH in 54 patients with first cycle of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) were determined. The values of each parameter in prediction of poor ovarian response were assessed using receiver-operating characteristic (ROC) curves. Results The serum AMH level of 11 patients (20.4%) with poor ovarian response (no more than five oocytes) was significantly lower than that of patients with normal ovarian response [(1.46±0.46) ng/mL vs (2.36±1.12) ng/mL, P<0.05]. ROC curve analysis revealed that area under curve (AUC) was 0.774 for AMH (P<0.01) and 0.728 for AFC (P<0.05), and AUC was less than 0.5 for each basal hormone (P>0.05). The sensitivity and specificity were 81.8% and 72.1%, respectively when the cutoff value of AMH was no higher than 1.64 ng/mL, and the sensitivity and specificity were 63.6% and 76.7%, respectively when the cutoff value of AFC was less than 6. Conclusion Serum AMH may serve as a predictor for poor ovarian response to exogenous gonadotrophin in patients undergoing controlled ovarian hyperstimulation.

Key words: anti-Müllerian hormone, ovarian stimulation, ovarian response